ID   VCaP-CR
AC   CVCL_A0BX
DR   cancercelllines; CVCL_A0BX
DR   GEO; GSM5402197
DR   Wikidata; Q108821488
RX   PubMed=34402095;
RX   PubMed=38892296;
CC   Population: Caucasian.
CC   Characteristics: Derived after a passage of the parent cell line in castrated nude mice.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
CC   Doubling time: ~60 hours (PubMed=34402095).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2235 ! VCaP
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 10-04-25; Version: 9
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RX   PubMed=34402095; DOI=10.1002/pros.24210; PMCID=PMC8460612;
RA   Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M.,
RA   Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J.L.,
RA   Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N.,
RA   Yegnasubramanian S.;
RT   "Phenotypic characterization of two novel cell line models of
RT   castration-resistant prostate cancer.";
RL   Prostate 81:1159-1171(2021).
//
RX   PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770;
RA   Beatson E.L., Risdon E.N., Napoli G.C., Price D.K., Chau C.H.,
RA   Figg W.D. Sr.;
RT   "Genomic characterization of preclinical prostate cancer cell line
RT   models.";
RL   Int. J. Mol. Sci. 25:6111.1-6111.19(2024).
//