ID   VCaP-CR
AC   CVCL_A0BX
DR   cancercelllines; CVCL_A0BX
DR   GEO; GSM5402197
DR   Wikidata; Q108821488
RX   PubMed=34402095;
RX   PubMed=38892296;
CC   Population: Caucasian.
CC   Characteristics: Derived after a passage of the parent cell line in castrated nude mice.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
CC   Doubling time: ~60 hours (PubMed=34402095).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2235 ! VCaP
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 10-04-25; Version: 9
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RX   PubMed=34402095; DOI=10.1002/pros.24210; PMCID=PMC8460612;
RA   Haffner, Michael C.
RA   Bhamidipati, Akshay
RA   Tsai, Harrison K.
RA   Esopi, David M.
RA   Vaghasia, Ajay M.
RA   Low, Jin-Yih
RA   Patel, Radhika A.
RA   Guner, Gunes
RA   Pham, Minh-Tam
RA   Castagna, Nicole
RA   Hicks, Jessica L.
RA   Wyhs, Nicolas
RA   Aebersold, Ruedi
RA   De Marzo, Angelo M.
RA   Nelson, William George
RA   Guo, Tian-Nan
RA   Yegnasubramanian, Srinivasan
RT   "Phenotypic characterization of two novel cell line models of
RT   castration-resistant prostate cancer.";
RL   Prostate 81:1159-1171(2021).
//
RX   PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770;
RA   Beatson, Erica L.
RA   Risdon, Emily N.
RA   Napoli, Giulia C.
RA   Price, Douglas K.
RA   Chau, Cindy H.
RA   Figg, William Douglas Sr.
RT   "Genomic characterization of preclinical prostate cancer cell line
RT   models.";
RL   Int. J. Mol. Sci. 25:6111.1-6111.19(2024).
//