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Cellosaurus 143BTK- (CVCL_9W36)

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Cell line name 143BTK-
Synonyms 143B/TK^(-)neo^(R)
Accession CVCL_9W36
Resource Identification Initiative To cite this cell line use: 143BTK- (RRID:CVCL_9W36)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P01117; Kirsten murine sarcoma virus k-Ras (v-Ki-ras).
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2270 (143B)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): RCB=RCB0701

Markers:
AmelogeninX
CSF1PO12
D5S81813
D7S82011,12
D13S31712
D16S53910,13
TH016
TPOX11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=3413074; DOI=10.1073/pnas.85.16.6042; PMCID=PMC281901
Olivia M. Pereira-Smith, James R. Smith;
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

Cross-references
Cell line collections (Providers) RCB; RCB0701
Cell line databases/resources CLO; CLO_0050098
cancercelllines; CVCL_9W36
Encyclopedic resources Wikidata; Q54581910
Gene expression databases FANTOM5_SSTAR; 10510-107D6
Entry history
Entry creation23-Feb-2016
Last entry update10-Apr-2025
Version number19