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Cellosaurus MNNG/HOS/DXR1000 (CVCL_9U38)

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Cell line name MNNG/HOS/DXR1000
Accession CVCL_9U38
Resource Identification Initiative To cite this cell line use: MNNG/HOS/DXR1000 (RRID:CVCL_9U38)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0439 (MNNG/HOS Cl #5)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Publications

PubMed=10854558; DOI=10.3892/or.7.4.859
Yoshinao Oda, Yoshihiro Matsumoto, Katsumi Harimaya, Yukihide Iwamoto, Masazumi Tsuneyoshi;
Establishment of new multidrug-resistant human osteosarcoma cell lines.
Oncol. Rep. 7:859-866(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9U38
Encyclopedic resources Wikidata; Q54906272
Entry history
Entry creation23-Feb-2016
Last entry update27-Nov-2025
Version number14