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Cellosaurus CTX0E03 (CVCL_9T00)

[Text version]
Cell line name CTX0E03
Synonyms CTXOE03; CTX-OE-03; CTX-OE03
Accession CVCL_9T00
Resource Identification Initiative To cite this cell line use: CTX0E03 (RRID:CVCL_9T00)
Comments Group: Patented cell line.
From: ReNeuron, Ltd; Pencoed; United Kingdom.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 04091601.
Doubling time: 3-4 days (Patent=US7666672).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7553; MYC.
Transformant: Myc.
Derived from site: In situ; Fetal brain, cerebral cortex; UBERON=UBERON_0006238+UBERON_0000956.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 12FW
Category Conditionally immortalized cell line
Web pages Info; LifeMap Discovery; -; https://web.archive.org/web/20241222163647/https://discovery.lifemapsc.com//stem-cell-differentiation/in-vitro-cells/brain-homo-sapiens-neural-stem-cell-line-ctx0e03-reneuron
Publications

PubMed=16464451; DOI=10.1016/j.expneurol.2005.12.011
Kenneth Pollock, Paul Stroemer, Sara Patel, Lara Stevanato, Andrew D. Hope, Erik A. Miljan, Zi-Ping Dong, Helen Hodges, Jack Price, John D. Sinden;
A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke.
Exp. Neurol. 199:143-155(2006)

PubMed=19343502; DOI=10.1007/s10529-009-9989-1
Robert James Thomas, Andrew D. Hope, Paul C. Hourd, Marc-Olivier Baradez, Erik A. Miljan, John D. Sinden, David J. Williams;
Automated, serum-free production of CTX0E03: a therapeutic clinical grade human neural stem cell line.
Biotechnol. Lett. 31:1167-1172(2009)

PubMed=19633272; DOI=10.1177/1545968309335978
Paul Stroemer, Sara Patel, Andrew D. Hope, Cathy Oliveira, Kenneth Pollock, John D. Sinden;
The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion.
Neurorehabil. Neural Repair 23:895-909(2009)

Patent=US7666672
John D. Sinden, Kenneth Pollock, Paul Stroemer;
Cell lines.
Patent number US7666672, 23-Feb-2010

PubMed=32374064; DOI=10.1002/stem.3191; PMCID=PMC7496241
Yongwoo Yoon, Hyun Sook Kim, Iksoo Jeon, Jeong-Eun Noh, Hyun Jung Park, Suji Lee, In-Hyun Park, Lara Stevanato, Caroline Hicks, Randolph Corteling, Roger Alistair Barker ...Show all 13 authors... , John D. Sinden, Jihwan Song; Show fewer authors
Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.
Stem Cells 38:936-947(2020)

Cross-references
Encyclopedic resources Wikidata; Q54814777
Entry history
Entry creation23-Feb-2016
Last entry update10-Apr-2025
Version number16