ID   CTX0E03
AC   CVCL_9T00
SY   CTXOE03; CTX-OE-03; CTX-OE03
DR   Wikidata; Q54814777
RX   Patent=US7666672;
RX   PubMed=16464451;
RX   PubMed=19343502;
RX   PubMed=19633272;
RX   PubMed=32374064;
WW   https://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/brain-homo-sapiens-neural-stem-cell-line-ctx0e03-reneuron
CC   Group: Patented cell line.
CC   From: ReNeuron, Ltd; Pencoed; United Kingdom.
CC   Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 04091601.
CC   Doubling time: 3-4 days (Patent=US7666672).
CC   Transfected with: HGNC; 7553; MYC.
CC   Transformant: Myc.
CC   Derived from site: In situ; Fetal brain, cerebral cortex; UBERON=UBERON_0006237+UBERON_0000956.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   12FW
CA   Conditionally immortalized cell line
DT   Created: 23-02-16; Last updated: 29-06-23; Version: 13
//
RX   Patent=US7666672;
RA   Sinden J.D., Pollock K., Stroemer P.;
RT   "Cell lines.";
RL   Patent number US7666672, 23-Feb-2010.
//
RX   PubMed=16464451; DOI=10.1016/j.expneurol.2005.12.011;
RA   Pollock K., Stroemer P., Patel S., Stevanato L., Hope A., Miljan E.A.,
RA   Dong Z.-P., Hodges H., Price J., Sinden J.D.;
RT   "A conditionally immortal clonal stem cell line from human cortical
RT   neuroepithelium for the treatment of ischemic stroke.";
RL   Exp. Neurol. 199:143-155(2006).
//
RX   PubMed=19343502; DOI=10.1007/s10529-009-9989-1;
RA   Thomas R.J., Hope A.D., Hourd P., Baradez M., Miljan E.A.,
RA   Sinden J.D., Williams D.J.;
RT   "Automated, serum-free production of CTX0E03: a therapeutic clinical
RT   grade human neural stem cell line.";
RL   Biotechnol. Lett. 31:1167-1172(2009).
//
RX   PubMed=19633272; DOI=10.1177/1545968309335978;
RA   Stroemer P., Patel S., Hope A., Oliveira C., Pollock K., Sinden J.D.;
RT   "The neural stem cell line CTX0E03 promotes behavioral recovery and
RT   endogenous neurogenesis after experimental stroke in a dose-dependent
RT   fashion.";
RL   Neurorehabil. Neural Repair 23:895-909(2009).
//
RX   PubMed=32374064; DOI=10.1002/stem.3191;
RA   Yoon Y., Kim H.S., Jeon I., Noh J.-E., Park H.J., Lee S., Park I.-H.,
RA   Stevanato L., Hicks C., Corteling R., Barker R.A., Sinden J.D.,
RA   Song J.;
RT   "Implantation of the clinical-grade human neural stem cell line,
RT   CTX0E03, rescues the behavioral and pathological deficits in the
RT   quinolinic acid-lesioned rodent model of Huntington's disease.";
RL   Stem Cells 38:936-947(2020).
//