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Cellosaurus IK-90 (CVCL_9996)

[Text version]

Cell line name IK-90
Accession CVCL_9996
Resource Identification Initiative To cite this cell line use: IK-90 (RRID:CVCL_9996)
Comments Population: Japanese.
Derived from sampling site: Endometrium.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Unexplicit; Ex10del; Zygosity=Heterozygous (PubMed=8105795).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (PubMed=8105795).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2529 (Ishikawa)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=3815380
Terakawa N., Hayashida M., Shimizu I., Ikegami H., Wakimoto H., Aono T., Tanizawa O., Matsumoto K., Nishida M.
Growth inhibition by progestins in a human endometrial cancer cell line with estrogen-independent progesterone receptors.
Cancer Res. 47:1918-1923(1987)

PubMed=8105795; DOI=10.1002/mc.2940080303
Enomoto T., Fujita M., Inoue M., Nakazawa-Miyamoto A., Tanizawa O., Nomura T.
Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma.
Mol. Carcinog. 8:132-137(1993)

Cross-references
Encyclopedic resources Wikidata; Q54897451
Polymorphism and mutation databases Cosmic; 735334
IARC_TP53; 2379
Entry history
Entry creation06-Jun-2012
Last entry update16-Dec-2021
Version number9