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Cellosaurus WB-F344 (CVCL_9806)

[Text version]
Cell line name WB-F344
Synonyms WB F344; WBF344
Accession CVCL_9806
Resource Identification Initiative To cite this cell line use: WB-F344 (RRID:CVCL_9806)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers. Expresses markers of liver progenitor cells, including EpCAM, Thy1, and Afp (Millipore=SCC253).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Fischer 344.
Hierarchy Children:
CVCL_DN33 (WB-5-11)CVCL_X199 (WB311)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line

PubMed=6468534; DOI=10.1016/0014-4827(84)90666-9
Tsao M.-S., Smith J.D., Nelson K.G., Grisham J.W.
A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells.
Exp. Cell Res. 154:38-52(1984)

PubMed=9745712; DOI=10.1111/j.1432-0436.1998.00215.x
Zvibel I., Fiorino A.S., Brill S., Reid L.M.
Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents.
Differentiation 63:215-223(1998)

PubMed=9846981; DOI=10.1016/S0002-9440(10)65705-7
Hooth M.J., Coleman W.B., Presnell S.C., Borchert K.M., Grisham J.W., Smith G.J.
Spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells.
Am. J. Pathol. 153:1913-1921(1998)

PubMed=20140209; DOI=10.1371/journal.pone.0009084
Jimenez R.H., Lee J.-S., Francesconi M., Castellani G., Neretti N., Sanders J.A., Sedivy J.M., Gruppuso P.A.
Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).
PLoS ONE 5:E9084-E9084(2010)

Cell line collections (Providers) CLS; 305201
Millipore; SCC253
Anatomy/cell type resources BTO; BTO:0004318
Encyclopedic resources Wikidata; Q54993590
Experimental variables resources EFO; EFO_0002871
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number15