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Cellosaurus WB-F344 (CVCL_9806)

[Text version]
Cell line name WB-F344
Synonyms WB F344; WBF344
Accession CVCL_9806
Resource Identification Initiative To cite this cell line use: WB-F344 (RRID:CVCL_9806)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers. Expresses markers of liver progenitor cells, including EpCAM, Thy1, and Afp (Millipore=SCC253).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Fischer 344; RS=RS_0000215.
Hierarchy Children:
CVCL_DN33 (WB-5-11)CVCL_X199 (WB311)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6468534; DOI=10.1016/0014-4827(84)90666-9
Ming-Sound Tsao, Judith D. Smith, Karen G. Nelson, Joe W. Grisham;
A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells.
Exp. Cell Res. 154:38-52(1984)

PubMed=9745712; DOI=10.1111/j.1432-0436.1998.00215.x
Isabel Zvibel, Anthony S. Fiorino, Shlomo Brill, Lola M. Reid;
Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents.
Differentiation 63:215-223(1998)

PubMed=9846981; DOI=10.1016/S0002-9440(10)65705-7; PMCID=PMC1866323
Michelle J. Hooth, William B. Coleman, Sharon C. Presnell, Kristen M. Borchert, Joe W. Grisham, Garry John Smith;
Spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells.
Am. J. Pathol. 153:1913-1921(1998)

PubMed=20140209; DOI=10.1371/journal.pone.0009084; PMCID=PMC2816708
Rosa H. Jimenez, Ju-Seog Lee, Mirko Francesconi, Gastone C. Castellani, Nicola Neretti, Jennifer A. Sanders, John Michael Sedivy, Philip Alan Gruppuso;
Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).
PLoS ONE 5:e9084.1-e9084.13(2010)

Cross-references
Cell line collections (Providers) CLS; 305201 - Discontinued
JCRB; JCRB0193
Millipore; SCC253
Anatomy/cell type resources BTO; BTO_0004318
Encyclopedic resources Wikidata; Q54993590
Experimental variables resources EFO; EFO_0002871
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number18