ID   WB-F344
AC   CVCL_9806
SY   WB F344; WBF344
DR   BTO; BTO_0004318
DR   EFO; EFO_0002871
DR   CLS; 305201
DR   JCRB; JCRB0193
DR   Millipore; SCC253
DR   Wikidata; Q54993590
RX   PubMed=6468534;
RX   PubMed=9745712;
RX   PubMed=9846981;
RX   PubMed=20140209;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers. Expresses markers of liver progenitor cells, including EpCAM, Thy1, and Afp (Millipore=SCC253).
CC   Omics: Transcriptomics; Microarray.
CC   Discontinued: CLS; 305201; true.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: Fischer 344; RS=RS_0000215.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 18
CH   CVCL_DN33 ! WB-5-11
CH   CVCL_X199 ! WB311
//
RX   PubMed=9846981; DOI=10.1016/S0002-9440(10)65705-7; PMCID=PMC1866323;
RA   Hooth, Michelle J.
RA   Coleman, William B.
RA   Presnell, Sharon C.
RA   Borchert, Kristen M.
RA   Grisham, Joe W.
RA   Smith, Garry John
RT   "Spontaneous neoplastic transformation of WB-F344 rat liver epithelial
RT   cells.";
RL   Am. J. Pathol. 153:1913-1921(1998).
//
RX   PubMed=6468534; DOI=10.1016/0014-4827(84)90666-9;
RA   Tsao, Ming-Sound
RA   Smith, Judith D.
RA   Nelson, Karen G.
RA   Grisham, Joe W.
RT   "A diploid epithelial cell line from normal adult rat liver with
RT   phenotypic properties of 'oval' cells.";
RL   Exp. Cell Res. 154:38-52(1984).
//
RX   PubMed=20140209; DOI=10.1371/journal.pone.0009084; PMCID=PMC2816708;
RA   Jimenez, Rosa H.
RA   Lee, Ju-Seog
RA   Francesconi, Mirko
RA   Castellani, Gastone C.
RA   Neretti, Nicola
RA   Sanders, Jennifer A.
RA   Sedivy, John Michael
RA   Gruppuso, Philip Alan
RT   "Regulation of gene expression in hepatic cells by the mammalian
RT   Target of Rapamycin (mTOR).";
RL   PLoS ONE 5:e9084.1-e9084.13(2010).
//
RX   PubMed=9745712; DOI=10.1111/j.1432-0436.1998.00215.x;
RA   Zvibel, Isabel
RA   Fiorino, Anthony S.
RA   Brill, Shlomo
RA   Reid, Lola M.
RT   "Phenotypic characterization of rat hepatoma cell lines and
RT   lineage-specific regulation of gene expression by differentiation
RT   agents.";
RL   Differentiation 63:215-223(1998).
//