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Cellosaurus SZ95 (CVCL_9803)

[Text version]
Cell line name SZ95
Synonyms SZ-95; SZ 95
Accession CVCL_9803
Resource Identification Initiative To cite this cell line use: SZ95 (RRID:CVCL_9803)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2383.
Doubling time: 52.4 +- 1.6 hours (PubMed=10594745).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVT).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Face, skin, sebaceous gland; UBERON=UBERON_0003487.
Cell type: Sebocyte; CL=CL_0000317.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 87Y
Category Transformed cell line
Web pages Info; ResearchGate; -; https://www.researchgate.net/post/Where-can-I-obtain-immortalized-human-sebocyte-cell-line-SZ95
Publications

PubMed=10594745; DOI=10.1046/j.1523-1747.1999.00771.x
Christos C. Zouboulis, Holger Seltmann, Heidemarie Neitzel, Constantin E. Orfanos;
Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).
J. Invest. Dermatol. 113:1011-1020(1999)

PubMed=18308950; DOI=10.1634/stemcells.2007-0651
Cristina Lo Celso, Melanie A. Berta, Kristin M. Braun, Michaela Frye, Stephen Lyle, Christos C. Zouboulis, Fiona Mary Watt;
Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin.
Stem Cells 26:1241-1252(2008)

PubMed=18690467; DOI=10.1007/s00403-008-0879-5
Christos C. Zouboulis, Silke Schagen, Theodosios Alestas;
The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne.
Arch. Dermatol. Res. 300:397-413(2008)

PubMed=20224690; DOI=10.4161/derm.1.2.8736; PMCID=PMC2835897
Lily Xia, Christos C. Zouboulis, Qiang Ju;
Culture of human sebocytes in vitro.
Dermato-Endocrinol. 1:92-95(2009)

PubMed=25061872; DOI=10.1172/JCI64628; PMCID=PMC4151231
Attila Olah, Balazs I. Toth, Istvan Borbiro, Koji Sugawara, Attila Gabor Szollosi, Gabriella Czifra, Balazs Pal, Lidia Ambrus, Jennifer Kloepper, Emanuela Camera, Matteo Ludovici ...Show all 16 authors... , Mauro Picardo, Thomas Voets, Christos C. Zouboulis, Ralf Paus, Tamas Biro; Show fewer authors
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.
J. Clin. Invest. 124:3713-3724(2014)

PubMed=25828468; DOI=10.1111/exd.12712
Georgios Nikolakis, Holger Seltmann, Amir M. Hossini, Evgenia Makrantonaki, Jurgen Knolle, Christos C. Zouboulis;
Ex vivo human skin and SZ95 sebocytes exhibit a homoeostatic interaction in a novel coculture contact model.
Exp. Dermatol. 24:497-502(2015)

Patent=US20160237406
Christos C. Zouboulis;
Sebocytes, sebocyte cell lines and applications thereof.
Patent number US20160237406, 18-Aug-2016

PubMed=29451719; DOI=10.1111/exd.13513
Marlon R. Schneider, Christos C. Zouboulis;
Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases.
Exp. Dermatol. 27:484-488(2018)

PubMed=29927962; DOI=10.1371/journal.pone.0198323; PMCID=PMC6013244
Daniel Torocsik, Dora Kovacs, Szilard Poliska, Zita Szentkereszty-Kovacs, Marianna Lovaszi, Katalin Hegyi, Andrea Szegedi, Christos C. Zouboulis, Mona Stahle;
Genome wide analysis of TLR1/2- and TLR4-activated SZ95 sebocytes reveals a complex immune-competence and identifies serum amyloid A as a marker for activated sebaceous glands.
PLoS ONE 13:e0198323.1-e0198323.20(2018)

Cross-references
Cell line databases/resources FCS-free; 31-2-33-2-4-3
Lonza; 489
Anatomy/cell type resources BTO; BTO_0003484
Encyclopedic resources Wikidata; Q54971318
Gene expression databases GEO; GSE57571
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number17