ID   SZ95
AC   CVCL_9803
SY   SZ-95; SZ 95
DR   BTO; BTO:0003484
DR   FCS-free; 31-2-33-2-4-3
DR   GEO; GSE57571
DR   Lonza; 489
DR   Wikidata; Q54971318
RX   Patent=US20160237406;
RX   PubMed=10594745;
RX   PubMed=18308950;
RX   PubMed=18690467;
RX   PubMed=20224690;
RX   PubMed=25061872;
RX   PubMed=25828468;
RX   PubMed=29451719;
RX   PubMed=29927962;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2383.
CC   Doubling time: 52.4 +- 1.6 hours (PubMed=10594745).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Face, skin, sebaceous gland; UBERON=UBERON_0003487.
CC   Cell type: Sebocyte; CL=CL_0000317.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   87Y
CA   Transformed cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 14
//
RX   Patent=US20160237406;
RA   Zouboulis C.C.;
RT   "Sebocytes, sebocyte cell lines and applications thereof.";
RL   Patent number US20160237406, 18-Aug-2016.
//
RX   PubMed=10594745; DOI=10.1046/j.1523-1747.1999.00771.x;
RA   Zouboulis C.C., Seltmann H., Neitzel H., Orfanos C.E.;
RT   "Establishment and characterization of an immortalized human sebaceous
RT   gland cell line (SZ95).";
RL   J. Invest. Dermatol. 113:1011-1020(1999).
//
RX   PubMed=18308950; DOI=10.1634/stemcells.2007-0651;
RA   Lo Celso C., Berta M.A., Braun K.M., Frye M., Lyle S., Zouboulis C.C.,
RA   Watt F.M.;
RT   "Characterization of bipotential epidermal progenitors derived from
RT   human sebaceous gland: contrasting roles of c-Myc and beta-catenin.";
RL   Stem Cells 26:1241-1252(2008).
//
RX   PubMed=18690467; DOI=10.1007/s00403-008-0879-5;
RA   Zouboulis C.C., Schagen S., Alestas T.;
RT   "The sebocyte culture: a model to study the pathophysiology of the
RT   sebaceous gland in sebostasis, seborrhoea and acne.";
RL   Arch. Dermatol. Res. 300:397-413(2008).
//
RX   PubMed=20224690; DOI=10.4161/derm.1.2.8736;
RA   Xia L., Zouboulis C.C., Ju Q.;
RT   "Culture of human sebocytes in vitro.";
RL   Dermato-Endocrinol. 1:92-95(2009).
//
RX   PubMed=25061872; DOI=10.1172/JCI64628;
RA   Olah A., Toth B.I., Borbiro I., Sugawara K., Szollosi A.G., Czifra G.,
RA   Pal B., Ambrus L., Kloepper J., Camera E., Ludovici M., Picardo M.,
RA   Voets T., Zouboulis C.C., Paus R., Biro T.;
RT   "Cannabidiol exerts sebostatic and antiinflammatory effects on human
RT   sebocytes.";
RL   J. Clin. Invest. 124:3713-3724(2014).
//
RX   PubMed=25828468; DOI=10.1111/exd.12712;
RA   Nikolakis G., Seltmann H., Hossini A.M., Makrantonaki E., Knolle J.,
RA   Zouboulis C.C.;
RT   "Ex vivo human skin and SZ95 sebocytes exhibit a homoeostatic
RT   interaction in a novel coculture contact model.";
RL   Exp. Dermatol. 24:497-502(2015).
//
RX   PubMed=29451719; DOI=10.1111/exd.13513;
RA   Schneider M.R., Zouboulis C.C.;
RT   "Primary sebocytes and sebaceous gland cell lines for studying
RT   sebaceous lipogenesis and sebaceous gland diseases.";
RL   Exp. Dermatol. 27:484-488(2018).
//
RX   PubMed=29927962; DOI=10.1371/journal.pone.0198323;
RA   Torocsik D., Kovacs D., Poliska S., Szentkereszty-Kovacs Z.,
RA   Lovaszi M., Hegyi K., Szegedi A., Zouboulis C.C., Stahle M.;
RT   "Genome wide analysis of TLR1/2- and TLR4-activated SZ95 sebocytes
RT   reveals a complex immune-competence and identifies serum amyloid A as
RT   a marker for activated sebaceous glands.";
RL   PLoS ONE 13:E0198323-E0198323(2018).
//