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Cellosaurus WIBR3 (CVCL_9767)

[Text version]
Cell line name WIBR3
Synonyms WIBR 3; WIBR38; WIBRe001-A
Accession CVCL_9767
Resource Identification Initiative To cite this cell line use: WIBR3 (RRID:CVCL_9767)
Comments From: Whitehead Institute for Biomedical Research; Boston; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0079.
Registration: Swiss research registry; BAG-hES-IMP-0051.
Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC11-58.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; ChIP-seq; H3K9me3.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His193Arg (c.578A>G); ClinVar=VCV000184979; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C7UU (WIBR3_DJ1_X1-5DEL_2073)CVCL_C7VA (WIBR3_FBXO7_FS_B6-1)CVCL_C7VC (WIBR3_FBXO7_R498X_G7-1)
CVCL_C7VE (WIBR3_GBA1_IVS2_D6B)CVCL_C7VK (WIBR3_LRRK2_G2019S_315_Homo)CVCL_E2W4 (WIBR3_PLA2G6_D331Y_A4_C2)
CVCL_E2W5 (WIBR3_PLA2G6_D331Y_A9_A4)CVCL_IU04 (WIBRe001-A-1)CVCL_C7V9 (WIBRe001-A-10)
CVCL_C7VL (WIBRe001-A-11)CVCL_C7VM (WIBRe001-A-12)CVCL_C7VN (WIBRe001-A-13)
CVCL_C7UY (WIBRe001-A-14)CVCL_C7UZ (WIBRe001-A-15)CVCL_C7V0 (WIBRe001-A-16)
CVCL_C7VF (WIBRe001-A-17)CVCL_C7VD (WIBRe001-A-18)CVCL_C7VW (WIBRe001-A-19)
CVCL_IU05 (WIBRe001-A-2)CVCL_C7VX (WIBRe001-A-20)CVCL_C7VY (WIBRe001-A-21)
CVCL_C7VG (WIBRe001-A-22)CVCL_C7VH (WIBRe001-A-23)CVCL_C7VI (WIBRe001-A-24)
CVCL_C7VJ (WIBRe001-A-25)CVCL_C7UV (WIBRe001-A-26)CVCL_C7UW (WIBRe001-A-27)
CVCL_C7UX (WIBRe001-A-28)CVCL_C8BD (WIBRe001-A-29)CVCL_C8BE (WIBRe001-A-30)
CVCL_C8BF (WIBRe001-A-31)CVCL_C7V1 (WIBRe001-A-32)CVCL_C7V2 (WIBRe001-A-33)
CVCL_C7V3 (WIBRe001-A-34)CVCL_C7V4 (WIBRe001-A-35)CVCL_C7V5 (WIBRe001-A-36)
CVCL_C7V6 (WIBRe001-A-37)CVCL_C7V7 (WIBRe001-A-38)CVCL_C7V8 (WIBRe001-A-39)
CVCL_C7VP (WIBRe001-A-4)CVCL_D3YC (WIBRe001-A-40)CVCL_C7VV (WIBRe001-A-41)
CVCL_C7VU (WIBRe001-A-42)CVCL_D3YP (WIBRe001-A-43)CVCL_D3YQ (WIBRe001-A-44)
CVCL_D3YN (WIBRe001-A-45)CVCL_D3YM (WIBRe001-A-46)CVCL_D3YE (WIBRe001-A-47)
CVCL_D3YD (WIBRe001-A-48)CVCL_D3Y9 (WIBRe001-A-49)CVCL_C7VQ (WIBRe001-A-5)
CVCL_D3Y8 (WIBRe001-A-50)CVCL_D3YB (WIBRe001-A-51)CVCL_D3Y7 (WIBRe001-A-52)
CVCL_D3YA (WIBRe001-A-53)CVCL_D3YL (WIBRe001-A-54)CVCL_D3YK (WIBRe001-A-55)
CVCL_D3YJ (WIBRe001-A-56)CVCL_D3YI (WIBRe001-A-57)CVCL_D3YH (WIBRe001-A-58)
CVCL_D3YG (WIBRe001-A-59)CVCL_C7VR (WIBRe001-A-6)CVCL_D3YF (WIBRe001-A-60)
CVCL_E2VZ (WIBRe001-A-61)CVCL_E2W0 (WIBRe001-A-62)CVCL_E2W1 (WIBRe001-A-63)
CVCL_E2W2 (WIBRe001-A-64)CVCL_E2W3 (WIBRe001-A-65)CVCL_E5GG (WIBRe001-A-66)
CVCL_E5GH (WIBRe001-A-67)CVCL_E5GI (WIBRe001-A-68)CVCL_E5GJ (WIBRe001-A-69)
CVCL_C7VS (WIBRe001-A-7)CVCL_C7VT (WIBRe001-A-8)CVCL_C7VB (WIBRe001-A-9)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=20471072; DOI=10.1016/j.cell.2010.04.010
Christopher J. Lengner, Alexander A. Gimelbrant, Jennifer Ann Erwin, Albert Wu Cheng, Matthew G. Guenther, G. Grant Welstead, Raaji Alagappan, Garrett M. Frampton, Ping Xu, Julien Muffat, Sandro Santagata ...Show all 17 authors... , Doug Powers, C. Brent Barrett, Richard Allen Young, Jeannie T. Lee, Rudolf Jaenisch, Maya Mitalipova; Show fewer authors
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.
Cell 141:872-883(2010)

PubMed=24172903; DOI=10.1038/nature12745
Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour, Yair S. Manor, Elad Chomsky, Dalit Ben-Yosef, Yael Kalma, Sergey Viukov, Itay Maza, Asaf Zviran, Yoach Rais ...Show all 27 authors... , Zohar Shipony, Zohar Mukamel, Vladislav Krupalnik, Mirie Zerbib, Shay Geula, Inbal Caspi, Dan Schneir, Tamar Shwartz, Shlomit Gilad, Daniela Amann-Zalcenstein, Sima Benjamin, Ido Amit, Amos Tanay, Rada Massarwa, Noa Novershtern, Jacob H. Hanna; Show fewer authors
Derivation of novel human ground state naive pluripotent stem cells.
Nature 504:282-286(2013)

PubMed=24936472; DOI=10.1016/j.stemcr.2014.03.014; PMCID=PMC4050353
Dorothea Maetzel, Sovan Sarkar, Hao-Yi Wang, Lina Abi-Mosleh, Ping Xu, Albert Wu Cheng, Qing Gao, Maya Mitalipova, Rudolf Jaenisch;
Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick type C patient-specific iPS cells.
Stem Cell Reports 2:866-880(2014)

PubMed=25090446; DOI=10.1016/j.stem.2014.07.002; PMCID=PMC4184977
Thorold W. Theunissen, Benjamin E. Powell, Hao-Yi Wang, Maya Mitalipova, Dina A. Faddah, Jessica Reddy, Zi-Peng Fan, Dorothea Maetzel, Kibibi Ganz, Lin-Yu Shi, Tenzin Lungjangwa ...Show all 21 authors... , Sumeth Imsoonthornruksa, Yonatan Stelzer, Sudharshan Rangarajan, Ana C. D'Alessio, Jian-Ming Zhang, Qing Gao, Meelad M. Dawlaty, Richard Allen Young, Nathanael S. Gray, Rudolf Jaenisch; Show fewer authors
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency.
Cell Stem Cell 15:471-487(2014)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

PubMed=38405931; DOI=10.1101/2024.02.12.579917; PMCID=PMC10888955
Oriol Busquets Figueras, Han-Qin Li, Khaja Mohieddin Syed, Pilar Alvarez Jerez, Jesse Dunnack, Riana Lo Bu, Yogendra Verma, Gabriella Rita Pangilinan, Annika Martin, Jannes Straub, Yu-Xin Du ...Show all 25 authors... , Vivien Madeleine Simon, Steven Poser, Zipporiah Bush, Jessica Diaz, Atehsa Sahagun, Jian-Pu Gao, Dena Godwin Hernandez, Kristin S. Levine, Ezgi O. Booth, Helen S. Bateup, Donald C. Rio, Dirk Hockemeyer, Cornelis Blauwendraat, Frank F. Soldner; Show fewer authors
iSCORE-PD: an isogenic stem cell collection to research Parkinson disease.
bioRxiv 2024:02.12.579917-02.12.579917(2024)

Cross-references
Cell line databases/resources hPSCreg; WIBRe001-A
NIHhESC; NIHhESC-10-0079
SKIP; SKIP002896
Biological sample resources BioSample; SAMN00010935
Encyclopedic resources Wikidata; Q54994042
Gene expression databases GEO; GSM523600
GEO; GSM523601
GEO; GSM529410
GEO; GSM529413
GEO; GSM529416
GEO; GSM529419
GEO; GSM1272761
GEO; GSM1272762
GEO; GSM1272763
GEO; GSM1272764
GEO; GSM1272765
GEO; GSM1272766
GEO; GSM1272767
GEO; GSM1272768
GEO; GSM1272769
GEO; GSM1272770
GEO; GSM1272771
GEO; GSM1272772
GEO; GSM1564930
GEO; GSM1564931
GEO; GSM1564932
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number23