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Cellosaurus KAS-6/1 (CVCL_9544)

[Text version]
Cell line name KAS-6/1
Synonyms KAS 6/1; KAS6/1; KAS-6; KAS61
Accession CVCL_9544
Resource Identification Initiative To cite this cell line use: KAS-6/1 (RRID:CVCL_9544)
Comments Characteristics: Produces IgG kappa.
Characteristics: IL6 dependent.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M524 ! KAS-6/2
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=8656685
Jennifer J. Westendorf, Gregory J. Ahmann, Philip Robert Greipp, Thomas E. Witzig, John Anthony Lust, Diane F. Jelinek;
Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6.
Leukemia 10:866-876(1996)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1182/blood.V112.11.2732.2732
Jonathan J. Keats, Bonnie K. Arendt, Esteban Braggio, Michael T. Barrett, Tammy L. Price-Troska, Rafael Fonseca, Peter Leif Bergsagel, Diane F. Jelinek;
Comparison of multiple myeloma donor patient samples and derived cell lines identifies a confirmed hyperdiploid myeloma cell line and demonstrates remarkable genetic similarity between cell lines and patient samples.
Blood 112 Suppl. 1:2732a-2732a(2008)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Amel Dib, Ana Gabrea, Oleg K. Glebov, Peter Leif Bergsagel, Walter Michael Kuehl;
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=24013424; DOI=10.4161/cc.26193; PMCID=PMC3865013
Denise K. Walters, Bonnie K. Arendt, Diane F. Jelinek;
CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.
Cell Cycle 12:3175-3183(2013)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54899506
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number18