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Cellosaurus YD-10B (CVCL_8929)

[Text version]
Cell line name YD-10B
Synonyms YD10B
Accession CVCL_8929
Resource Identification Initiative To cite this cell line use: YD-10B (RRID:CVCL_8929)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Korean.
Doubling time: 25.3 hours (PubMed=16264262).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu88Ter (c.262G>T); ClinVar=VCV000376305; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Trp110Ter (c.330G>A) (p.Gly125Arg, c.373G>A); ClinVar=VCV000376303; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr236Ter (c.708C>A); Zygosity=Homozygous (PubMed=16264262; DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:06,33:03
HLA-BB*51:01,58:01
HLA-CC*03:02,14:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North62.45
East Asian, South36.59
South Asian0
European, North0
European, South0.96
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=16264262

Markers:
AmelogeninX,Y
CSF1PO12,13
D3S135817
D5S81811,13
D7S82011
D8S117911
D13S3178,9 (KCLB)
9 (PubMed=16264262)
D16S53910,11
D18S5114
D21S1130,32
DXS10122
DYS39110
FGA23
Penta D8,9
Penta E5,8
TH016,9
TPOX8
vWA18,19 (KCLB)
18,19,20 (PubMed=16264262)

Run an STR similarity search on this cell line
Publications

PubMed=16264262; DOI=10.1038/emm.2005.48
Lee E.J., Kim J., Lee S.A., Kim E.-J., Chun Y.-C., Ryu M.H., Yook J.-I.
Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells.
Exp. Mol. Med. 37:379-390(2005)

PubMed=17404023; DOI=10.1196/annals.1397.014
Kwak Y.E., Jeon N.K., Kim J., Lee E.J.
The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma.
Ann. N. Y. Acad. Sci. 1095:99-112(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23708675; DOI=10.3892/ijo.2013.1953
Oh J.-E., Kim J.-O., Shin J.-Y., Zhang X.-H., Won H.-S., Chun S.-H., Jung C.-K., Park W.-S., Nam S.-W., Eun J.-W., Kang J.-H.
Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes.
Int. J. Oncol. 43:383-393(2013)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) KCLB; 60503
Cell line databases/resources cancercelllines; CVCL_8929
Cell_Model_Passport; SIDM01782
DepMap; ACH-000723
Biological sample resources BioSample; SAMN10987734
Chemistry resources PharmacoDB; YD10B_1680_2019
Encyclopedic resources Wikidata; Q54995381
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887743
GEO; GSM888838
Polymorphism and mutation databases IARC_TP53; 21618
LiGeA; CCLE_770
Progenetix; CVCL_8929
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number29