ID   YD-10B
AC   CVCL_8929
SY   YD10B
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10987734
DR   cancercelllines; CVCL_8929
DR   Cell_Model_Passport; SIDM01782
DR   DepMap; ACH-000723
DR   GEO; GSM887743
DR   GEO; GSM888838
DR   IARC_TP53; 21618
DR   KCLB; 60503
DR   LiGeA; CCLE_770
DR   PharmacoDB; YD10B_1680_2019
DR   Progenetix; CVCL_8929
DR   Wikidata; Q54995381
RX   PubMed=16264262;
RX   PubMed=17404023;
RX   PubMed=22460905;
RX   PubMed=23708675;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Korean.
CC   Doubling time: 25.3 hours (PubMed=16264262).
CC   HLA typing: A*02:06,33:03; B*51:01,58:01; C*03:02,14:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu88Ter (c.262G>T); ClinVar=VCV000376305; Zygosity=Heterozygous (DepMap).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Trp110Ter (c.330G>A) (p.Gly125Arg, c.373G>A); ClinVar=VCV000376303; Zygosity=Heterozygous (DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr236Ter (c.708C>A); Zygosity=Homozygous (PubMed=16264262; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=62.45%; East Asian, South=36.59%; South Asian=0%; European, North=0%; European, South=0.96% (PubMed=30894373).
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): KCLB; PubMed=16264262
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 8,9 (KCLB)
ST   D13S317: 9 (PubMed=16264262)
ST   D16S539: 10,11
ST   D18S51: 14
ST   D21S11: 30,32
ST   D3S1358: 17
ST   D5S818: 11,13
ST   D7S820: 11
ST   D8S1179: 11
ST   DXS101: 22
ST   DYS391: 10
ST   FGA: 23
ST   Penta D: 8,9
ST   Penta E: 5,8
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 18,19 (KCLB)
ST   vWA: 18,19,20 (PubMed=16264262)
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 29
//
RX   PubMed=16264262; DOI=10.1038/emm.2005.48;
RA   Lee E.J., Kim J., Lee S.A., Kim E.-J., Chun Y.-C., Ryu M.H.,
RA   Yook J.-I.;
RT   "Characterization of newly established oral cancer cell lines derived
RT   from six squamous cell carcinoma and two mucoepidermoid carcinoma
RT   cells.";
RL   Exp. Mol. Med. 37:379-390(2005).
//
RX   PubMed=17404023; DOI=10.1196/annals.1397.014;
RA   Kwak Y.E., Jeon N.K., Kim J., Lee E.J.;
RT   "The cyclooxygenase-2 selective inhibitor celecoxib suppresses
RT   proliferation and invasiveness in the human oral squamous carcinoma.";
RL   Ann. N. Y. Acad. Sci. 1095:99-112(2007).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23708675; DOI=10.3892/ijo.2013.1953;
RA   Oh J.-E., Kim J.-O., Shin J.-Y., Zhang X.-H., Won H.-S., Chun S.-H.,
RA   Jung C.-K., Park W.-S., Nam S.-W., Eun J.-W., Kang J.-H.;
RT   "Molecular genetic characterization of p53 mutated oropharyngeal
RT   squamous cell carcinoma cells transformed with human papillomavirus E6
RT   and E7 oncogenes.";
RL   Int. J. Oncol. 43:383-393(2013).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//