• Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  
• Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
  

PubMed=1453773
Estelle Duprez, Sandrine Ruchaud, Gunnar Houge, V. Martin-Thouvenin, Francoise Valensi, Philippe Kastner, Roland Berger, Michel Lanotte;
A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.
Leukemia 6:1281-1287(1992)

PubMed=7915840; DOI=10.1073/pnas.91.18.8428; PMCID=PMC44619
Sandrine Ruchaud, Estelle Duprez, Marie-Claude Gendron, Gunnar Houge, Hans-Gottfried Genieser, Bernd Jastorff, Stein Ove Doskeland, Michel Lanotte;
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Proc. Natl. Acad. Sci. U.S.A. 91:8428-8432(1994)

PubMed=7630193
Arlette Bruel, Gerard Benoit, Daniele De Nay, Spencer Craig Brown, Michel Lanotte;
Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression.
Leukemia 9:1173-1184(1995)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Mathilde J.S. Roussel, Michel Lanotte;
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)