ID   NB4-LR1
AC   CVCL_8811
SY   NB4-RAr; NB4-R1
DR   BTO; BTO_0006043
DR   cancercelllines; CVCL_8811
DR   Wikidata; Q54907532
RX   PubMed=1453773;
RX   PubMed=7630193;
RX   PubMed=7915840;
RX   PubMed=11704857;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0005 ! NB4
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 20
//
RX   PubMed=1453773;
RA   Duprez E., Ruchaud S., Houge G., Martin-Thouvenin V., Valensi F.,
RA   Kastner P., Berger R., Lanotte M.;
RT   "A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia
RT   cell line: isolation, morphological, immunological, and molecular
RT   features.";
RL   Leukemia 6:1281-1287(1992).
//
RX   PubMed=7630193;
RA   Bruel A., Benoit G., De Nay D., Brown S., Lanotte M.;
RT   "Distinct apoptotic responses in maturation sensitive and resistant
RT   t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid
RT   induces apoptosis independent of maturation and Bcl-2 expression.";
RL   Leukemia 9:1173-1184(1995).
//
RX   PubMed=7915840; DOI=10.1073/pnas.91.18.8428; PMCID=PMC44619;
RA   Ruchaud S., Duprez E., Gendron M.-C., Houge G., Genieser H.-G.,
RA   Jastorff B., Doskeland S.O., Lanotte M.;
RT   "Two distinctly regulated events, priming and triggering, during
RT   retinoid-induced maturation and resistance of NB4 promyelocytic
RT   leukemia cell line.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:8428-8432(1994).
//
RX   PubMed=11704857; DOI=10.1038/sj.onc.1204863;
RA   Roussel M.J.S., Lanotte M.;
RT   "Maturation sensitive and resistant t(15;17) NB4 cell lines as tools
RT   for APL physiopathology: nomenclature of cells and repertory of their
RT   known genetic alterations and phenotypes.";
RL   Oncogene 20:7287-7291(2001).
//