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Cellosaurus OCI-Ly10 (CVCL_8795)

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Cell line name OCI-Ly10
Synonyms OCI-LY10; OCI-LY-10; OCI-Ly 10; OCILY-10; OCI Ly10; OCILY10; OCILy10; Ly10; LY10
Accession CVCL_8795
Resource Identification Initiative To cite this cell line use: OCI-Ly10 (RRID:CVCL_8795)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:1698; CD79A; Simple; p.Leu191_Gly208del; Zygosity=Heterozygous (PubMed=20054396).
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=21179087).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,24:02
HLA-BB*40:02,40:02
HLA-CC*03:04,03:04
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.25
Native American0.93
East Asian, North0.48
East Asian, South0
South Asian0.05
European, North70.29
European, South28
Disease Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D3S135816
D5S81810,12
D7S82010,11
D8S117913,14
D13S31711,12
D16S53913
D18S5114,18
D21S1129
FGA20
Penta D9
Penta E14,17
TH016,7
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=3567358; DOI=10.1182/blood.V69.5.1307.1307
Mary Elizabeth Tweeddale, Bing Lim, Nazir Jamal, Jean Robinson, John Raymond Zalcberg, Gina Lockwood, Mark David Minden, Hans August Messner;
The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.
Blood 69:1307-1314(1987)

PubMed=8574164; DOI=10.3109/10428199509059672
Hong Chang, John A. Blondal, Sam Benchimol, Mark David Minden, Hans August Messner;
p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines.
Leuk. Lymphoma 19:165-171(1995)

PubMed=10676951; DOI=10.1038/35000501
Ash Arash Alizadeh, Michael Bruce Eisen, R. Eric Davis, Chi Ma, Izidore S. Lossos, Andreas Rosenwald, Jennifer Connolly Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John I. Powell ...Show all 31 authors... , Li-Ming Yang, Gerald E. Marti, Troy Moore, James Hudson Jr., Li-Sheng Lu, David B. Lewis, Robert Tibshirani, Gavin Sherlock, Wing-Chung Chan, Timothy Charles Greiner, Dennis D. Weisenburger, James Olen Armitage, Roger Allen Warnke, Ronald Levy, Wyndham H. Wilson, Michael Rhodes Grever, John C. Byrd, David Botstein, Patrick O'Reilly Brown, Louis Michael Staudt; Show fewer authors
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Nature 403:503-511(2000)

PubMed=15122589; DOI=10.1002/ijc.20170
Amanda P. Liggins, Barbara Ann Guinn, Chris S. Hatton, Karen Pulford, Alison H. Banham;
Serologic detection of diffuse large B-cell lymphoma-associated antigens.
Int. J. Cancer 110:563-569(2004)

PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535
R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul Bernard Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yan-Dan Yang, Wei-Hong Xu ...Show all 37 authors... , Arthur L. Shaffer 3rd, George Wright, Wen-Ming Xiao, John I. Powell, Jian-Kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans-Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Susan Keen Pierce, Louis Michael Staudt; Show fewer authors
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature 463:88-92(2010)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Michael Richard Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd Robert Golub, Jeffery L. Kutok, Margaret Ann Shipp;
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=20889926; DOI=10.1182/blood-2010-06-290437; PMCID=PMC3037744
Lan V. Pham, Ling-Chen Fu, Archito T. Tamayo, Carlos E. Bueso-Ramos, Elias Drakos, Francisco Vega-Vazquez, L. Jeffrey Medeiros, Richard Joseph Ford Jr.;
Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-kappaB-inducing kinase while activating both canonical and alternative nuclear factor-kappaB pathways.
Blood 117:200-210(2011)

PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568
Vu N. Ngo, Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wen-Ming Xiao, Kian-Huat Lim, Holger Kohlhammer, Wei-Hong Xu, Yan-Dan Yang, Hong Zhao, Arthur L. Shaffer 3rd ...Show all 31 authors... , Paul Bernard Romesser, George Wright, John I. Powell, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Louis Michael Staudt; Show fewer authors
Oncogenically active MYD88 mutations in human lymphoma.
Nature 470:115-119(2011)

PubMed=23257783; DOI=10.1038/leu.2012.367
Soren-Sebastian Wenzel, Michael Grau, Cory Mavis, Stephan Hailfinger, Annette Wolf, Hannelore Madle, George Deeb, Bernd Dorken, Margot Thome, Peter Lenz, Stefan Dirnhofer ...Show all 14 authors... , Francisco Javier Hernandez-Ilizaliturri, Alexandar Tzankov, Georg Lenz; Show fewer authors
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051
Jenny Zhang, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr Andrzej Mieczkowski, Cherie Dunphy, William Wai-Lap Choi, Wing Yan Au, Gopesh Srivastava, Patricia Lynne Lugar ...Show all 36 authors... , David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher Robert Flowers, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Magdalena B. Czader, Javed Iqbal Gill, Eric Darryl Hsi, Qing-Quan Liu, Alice Fan, Katherine Walsh, Dereje Jima, Lisa L. Smith, Amy J. Johnson, John C. Byrd, Micah Alan Luftig, Ting Ni, Jun Zhu, Amy Chadburn, Shawn Levy, David Brian Dunson, Sandeep S. Dave; Show fewer authors
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717
Joseph D. Dekker, Daechan Park, Arthur L. Shaffer 3rd, Holger Kohlhammer, Wei Deng, Bum-Kyu Lee, Gregory C. Ippolito, George Georgiou, Vishwanath R. Iyer, Louis Michael Staudt, Haley O. Tucker;
Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.
Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470
Wei Liu, Juan Chen, Archito T. Tamayo, Chang-Geng Ruan, Li Li, Shou-Hao Zhou, Chan Shen, Ken H. Young, Jason Westin, Richard E. Davis, Shi-Min Hu ...Show all 14 authors... , L. Jeffrey Medeiros, Richard Joseph Ford Jr., Lan V. Pham; Show fewer authors
Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.
Oncotarget 9:346-360(2018)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8795
Cell_Model_Passport; SIDM01883
DepMap; ACH-001146
Lonza; 944
Biological sample resources BioSample; SAMN03470849
BioSample; SAMN10988192
Chemistry resources ChEMBL-Cells; CHEMBL4482983
ChEMBL-Targets; CHEMBL4483285
PharmacoDB; OCILY10_1188_2019
PubChem_Cell_line; CVCL_8795
Encyclopedic resources Wikidata; Q54931760
Experimental variables resources EFO; EFO_0006708
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM1956
GEO; GSM2015
GEO; GSM2071
GEO; GSM552455
GEO; GSM1035340
GEO; GSM1059800
GEO; GSM1374784
GEO; GSM1890029
GEO; GSM1890030
GEO; GSM1890031
GEO; GSM1890032
Polymorphism and mutation databases Cosmic; 1134604
Cosmic; 1329095
Cosmic; 1486585
Cosmic; 1487547
Cosmic; 1517650
Cosmic; 1541905
Cosmic; 1550338
Cosmic; 1945184
Cosmic; 2139542
Cosmic; 2276333
Cosmic; 2437310
Progenetix; CVCL_8795
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number36