ID   OCI-Ly10
AC   CVCL_8795
SY   OCI-LY10; OCI-LY-10; OCI-Ly 10; OCILY-10; OCI Ly10; OCILY10; OCILy10; Ly10; LY10
DR   EFO; EFO_0006708
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03470849
DR   BioSample; SAMN10988192
DR   cancercelllines; CVCL_8795
DR   Cell_Model_Passport; SIDM01883
DR   ChEMBL-Cells; CHEMBL4482983
DR   ChEMBL-Targets; CHEMBL4483285
DR   Cosmic; 1134604
DR   Cosmic; 1329095
DR   Cosmic; 1486585
DR   Cosmic; 1487547
DR   Cosmic; 1517650
DR   Cosmic; 1541905
DR   Cosmic; 1550338
DR   Cosmic; 1945184
DR   Cosmic; 2139542
DR   Cosmic; 2276333
DR   Cosmic; 2437310
DR   DepMap; ACH-001146
DR   EGA; EGAS00001000610
DR   GEO; GSM1956
DR   GEO; GSM2015
DR   GEO; GSM2071
DR   GEO; GSM552455
DR   GEO; GSM1035340
DR   GEO; GSM1059800
DR   GEO; GSM1374784
DR   GEO; GSM1890029
DR   GEO; GSM1890030
DR   GEO; GSM1890031
DR   GEO; GSM1890032
DR   Lonza; 944
DR   PharmacoDB; OCILY10_1188_2019
DR   Progenetix; CVCL_8795
DR   PubChem_Cell_line; CVCL_8795
DR   Wikidata; Q54931760
RX   PubMed=3567358;
RX   PubMed=8574164;
RX   PubMed=10676951;
RX   PubMed=15122589;
RX   PubMed=20054396;
RX   PubMed=20628145;
RX   PubMed=20889926;
RX   PubMed=21179087;
RX   PubMed=23257783;
RX   PubMed=23292937;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=26787899;
RX   PubMed=28196595;
RX   PubMed=29416618;
RX   PubMed=29666304;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   From: Ontario Cancer Institute (OCI); Toronto; Canada.
CC   Population: Caucasian.
CC   HLA typing: A*02:01,24:02; B*40:02,40:02; C*03:04,03:04 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:1698; CD79A; Simple; p.Leu191_Gly208del; Zygosity=Heterozygous (PubMed=20054396).
CC   Sequence variation: Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=21179087).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.25%; Native American=0.93%; East Asian, North=0.48%; East Asian, South=0%; South Asian=0.05%; European, North=70.29%; European, South=28% (PubMed=30894373).
CC   Derived from site: In situ; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 13
ST   D18S51: 14,18
ST   D21S11: 29
ST   D3S1358: 16
ST   D5S818: 10,12
ST   D7S820: 10,11
ST   D8S1179: 13,14
ST   FGA: 20
ST   Penta D: 9
ST   Penta E: 14,17
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C36081; Diffuse large B-cell lymphoma activated B-cell type
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 14-08-25; Version: 36
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=8574164; DOI=10.3109/10428199509059672;
RA   Chang, Hong
RA   Blondal, John A.
RA   Benchimol, Sam
RA   Minden, Mark David
RA   Messner, Hans August
RT   "p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's
RT   lymphoma cell lines.";
RL   Leuk. Lymphoma 19:165-171(1995).
//
RX   PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356;
RA   Green, Michael Richard
RA   Monti, Stefano
RA   Rodig, Scott J.
RA   Juszczynski, Przemyslaw
RA   Currie, Treeve
RA   O'Donnell, Evan
RA   Chapuy, Bjoern
RA   Takeyama, Kunihiko
RA   Neuberg, Donna
RA   Golub, Todd Robert
RA   Kutok, Jeffery L.
RA   Shipp, Margaret Ann
RT   "Integrative analysis reveals selective 9p24.1 amplification,
RT   increased PD-1 ligand expression, and further induction via JAK2 in
RT   nodular sclerosing Hodgkin lymphoma and primary mediastinal large
RT   B-cell lymphoma.";
RL   Blood 116:3268-3277(2010).
//
RX   PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717;
RA   Dekker, Joseph D.
RA   Park, Daechan
RA   Shaffer, Arthur L. 3rd
RA   Kohlhammer, Holger
RA   Deng, Wei
RA   Lee, Bum-Kyu
RA   Ippolito, Gregory C.
RA   Georgiou, George
RA   Iyer, Vishwanath R.
RA   Staudt, Louis Michael
RA   Tucker, Haley O.
RT   "Subtype-specific addiction of the activated B-cell subset of diffuse
RT   large B-cell lymphoma to FOXP1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004;
RA   Pham, Lan V.
RA   Huang, Sheng-Jian
RA   Zhang, Hui
RA   Zhang, Jun
RA   Bell, Taylor
RA   Zhou, Shou-Hao
RA   Pogue, Elizabeth
RA   Ding, Zhi-Yong
RA   Lam, Laura
RA   Westin, Jason
RA   Davis, R. Eric
RA   Young, Ken H.
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RA   Nomie, Krystle
RA   Zhang, Leo
RA   Wang, Michael
RT   "Strategic therapeutic targeting to overcome venetoclax resistance in
RT   aggressive B-cell lymphomas.";
RL   Clin. Cancer Res. 24:3967-3980(2018).
//
RX   PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568;
RA   Ngo, Vu N.
RA   Young, Ryan M.
RA   Schmitz, Roland
RA   Jhavar, Sameer
RA   Xiao, Wen-Ming
RA   Lim, Kian-Huat
RA   Kohlhammer, Holger
RA   Xu, Wei-Hong
RA   Yang, Yan-Dan
RA   Zhao, Hong
RA   Shaffer, Arthur L. 3rd
RA   Romesser, Paul Bernard
RA   Wright, George
RA   Powell, John I.
RA   Rosenwald, Andreas
RA   Muller-Hermelink, Hans-Konrad
RA   Ott, German
RA   Gascoyne, Randy D.
RA   Connors, Joseph M.
RA   Rimsza, Lisa M.
RA   Campo, Elias
RA   Jaffe, Elaine Sarkin
RA   Delabie, Jan
RA   Smeland, Erlend Bremertun
RA   Fisher, Richard I.
RA   Braziel, Rita Merle
RA   Tubbs, Raymond Roy
RA   Cook, James R.
RA   Weisenburger, Dennis D.
RA   Chan, Wing-Chung
RA   Staudt, Louis Michael
RT   "Oncogenically active MYD88 mutations in human lymphoma.";
RL   Nature 470:115-119(2011).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470;
RA   Liu, Wei
RA   Chen, Juan
RA   Tamayo, Archito T.
RA   Ruan, Chang-Geng
RA   Li, Li
RA   Zhou, Shou-Hao
RA   Shen, Chan
RA   Young, Ken H.
RA   Westin, Jason
RA   Davis, Richard E.
RA   Hu, Shi-Min
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RA   Pham, Lan V.
RT   "Preclinical efficacy and biological effects of the oral proteasome
RT   inhibitor ixazomib in diffuse large B-cell lymphoma.";
RL   Oncotarget 9:346-360(2018).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=23257783; DOI=10.1038/leu.2012.367;
RA   Wenzel, Soren-Sebastian
RA   Grau, Michael
RA   Mavis, Cory
RA   Hailfinger, Stephan
RA   Wolf, Annette
RA   Madle, Hannelore
RA   Deeb, George
RA   Dorken, Bernd
RA   Thome, Margot
RA   Lenz, Peter
RA   Dirnhofer, Stefan
RA   Hernandez-Ilizaliturri, Francisco Javier
RA   Tzankov, Alexandar
RA   Lenz, Georg
RT   "MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.";
RL   Leukemia 27:1381-1390(2013).
//
RX   PubMed=15122589; DOI=10.1002/ijc.20170;
RA   Liggins, Amanda P.
RA   Guinn, Barbara Ann
RA   Hatton, Chris S.
RA   Pulford, Karen
RA   Banham, Alison H.
RT   "Serologic detection of diffuse large B-cell lymphoma-associated
RT   antigens.";
RL   Int. J. Cancer 110:563-569(2004).
//
RX   PubMed=3567358; DOI=10.1182/blood.V69.5.1307.1307;
RA   Tweeddale, Mary Elizabeth
RA   Lim, Bing
RA   Jamal, Nazir
RA   Robinson, Jean
RA   Zalcberg, John Raymond
RA   Lockwood, Gina
RA   Minden, Mark David
RA   Messner, Hans August
RT   "The presence of clonogenic cells in high-grade malignant lymphoma: a
RT   prognostic factor.";
RL   Blood 69:1307-1314(1987).
//
RX   PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051;
RA   Zhang, Jenny
RA   Grubor, Vladimir
RA   Love, Cassandra L.
RA   Banerjee, Anjishnu
RA   Richards, Kristy L.
RA   Mieczkowski, Piotr Andrzej
RA   Dunphy, Cherie
RA   Choi, William Wai-Lap
RA   Au, Wing Yan
RA   Srivastava, Gopesh
RA   Lugar, Patricia Lynne
RA   Rizzieri, David A.
RA   Lagoo, Anand S.
RA   Bernal-Mizrachi, Leon
RA   Mann, Karen P.
RA   Flowers, Christopher Robert
RA   Naresh, Kikkeri N.
RA   Evens, Andrew M.
RA   Gordon, Leo I.
RA   Czader, Magdalena Beata
RA   Gill, Javed Iqbal
RA   Hsi, Eric Darryl
RA   Liu, Qing-Quan
RA   Fan, Alice
RA   Walsh, Katherine
RA   Jima, Dereje
RA   Smith, Lisa L.
RA   Johnson, Amy J.
RA   Byrd, John C.
RA   Luftig, Micah Alan
RA   Ni, Ting
RA   Zhu, Jun
RA   Chadburn, Amy
RA   Levy, Shawn
RA   Dunson, David Brian
RA   Dave, Sandeep S.
RT   "Genetic heterogeneity of diffuse large B-cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20889926; DOI=10.1182/blood-2010-06-290437; PMCID=PMC3037744;
RA   Pham, Lan V.
RA   Fu, Ling-Chen
RA   Tamayo, Archito T.
RA   Bueso-Ramos, Carlos E.
RA   Drakos, Elias
RA   Vega-Vazquez, Francisco
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RT   "Constitutive BR3 receptor signaling in diffuse, large B-cell
RT   lymphomas stabilizes nuclear factor-kappaB-inducing kinase while
RT   activating both canonical and alternative nuclear factor-kappaB
RT   pathways.";
RL   Blood 117:200-210(2011).
//
RX   PubMed=10676951; DOI=10.1038/35000501;
RA   Alizadeh, Ash Arash
RA   Eisen, Michael Bruce
RA   Davis, R. Eric
RA   Ma, Chi
RA   Lossos, Izidore S.
RA   Rosenwald, Andreas
RA   Boldrick, Jennifer Connolly
RA   Sabet, Hajeer
RA   Tran, Truc
RA   Yu, Xin
RA   Powell, John I.
RA   Yang, Li-Ming
RA   Marti, Gerald E.
RA   Moore, Troy
RA   Hudson, James Jr.
RA   Lu, Li-Sheng
RA   Lewis, David B.
RA   Tibshirani, Robert John
RA   Sherlock, Gavin
RA   Chan, Wing-Chung
RA   Greiner, Timothy Charles
RA   Weisenburger, Dennis D.
RA   Armitage, James Olen
RA   Warnke, Roger Allen
RA   Levy, Ronald
RA   Wilson, Wyndham H.
RA   Grever, Michael Rhodes
RA   Byrd, John C.
RA   Botstein, David
RA   Brown, Patrick O'Reilly
RA   Staudt, Louis Michael
RT   "Distinct types of diffuse large B-cell lymphoma identified by gene
RT   expression profiling.";
RL   Nature 403:503-511(2000).
//
RX   PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535;
RA   Davis, R. Eric
RA   Ngo, Vu N.
RA   Lenz, Georg
RA   Tolar, Pavel
RA   Young, Ryan M.
RA   Romesser, Paul Bernard
RA   Kohlhammer, Holger
RA   Lamy, Laurence
RA   Zhao, Hong
RA   Yang, Yan-Dan
RA   Xu, Wei-Hong
RA   Shaffer, Arthur L. 3rd
RA   Wright, George
RA   Xiao, Wen-Ming
RA   Powell, John I.
RA   Jiang, Jian-Kang
RA   Thomas, Craig J.
RA   Rosenwald, Andreas
RA   Ott, German
RA   Muller-Hermelink, Hans-Konrad
RA   Gascoyne, Randy D.
RA   Connors, Joseph M.
RA   Johnson, Nathalie A.
RA   Rimsza, Lisa M.
RA   Campo, Elias
RA   Jaffe, Elaine Sarkin
RA   Wilson, Wyndham H.
RA   Delabie, Jan
RA   Smeland, Erlend Bremertun
RA   Fisher, Richard I.
RA   Braziel, Rita Merle
RA   Tubbs, Raymond Roy
RA   Cook, James R.
RA   Weisenburger, Dennis D.
RA   Chan, Wing-Chung
RA   Pierce, Susan Keen
RA   Staudt, Louis Michael
RT   "Chronic active B-cell-receptor signalling in diffuse large B-cell
RT   lymphoma.";
RL   Nature 463:88-92(2010).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//