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Cellosaurus WM793 (CVCL_8787)

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Cell line name WM793
Synonyms WM-793; WM 793; WML 793; WM793B; WM-793B; WM 793B; WM793b; WC00062
Accession CVCL_8787
Secondary accession CVCL_5414
Resource Identification Initiative To cite this cell line use: WM793 (RRID:CVCL_8787)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: D18S51: 11,14->14,15.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=16827748; PubMed=18632627; PubMed=23851445; PubMed=24576830; Cosmic-CLP=1299081; DepMap=ACH-000827; Wistar).
  • Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Lys22Gln (c.64A>C); ClinVar=VCV000485487; Zygosity=Homozygous (PubMed=23851445; Cosmic-CLP=1299081; DepMap=ACH-000827; Wistar).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Trp274Ter (c.821G>A); ClinVar=VCV001762511; Zygosity=Heterozygous (PubMed=23851445; Cosmic-CLP=1299081; DepMap=ACH-000827).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*01:01,29:01
HLA-BB*35:01,57:01
HLA-CC*04:01:01,06:02
Class II
HLA-DPDPB1*04:01,04:01
HLA-DQDQB1*03:01:01,03:01:01
HLA-DRDRB1*11:03:01,11:03:01

Source: PubMed=26589293
Class I
HLA-AA*01:01,29:01
HLA-BB*35:02,57:01
HLA-CC*04:01,06:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.43
Native American0.27
East Asian, North4.02
East Asian, South1.29
South Asian5.85
European, North24.77
European, South61.38
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5239 (1205Lu)CVCL_A800 (WM793-P1N1)CVCL_A801 (WM793-P1N2)
CVCL_A802 (WM793-P1N3)CVCL_A803 (WM793-P2N1)CVCL_A804 (WM793-P2N2)
CVCL_A805 (WM793-P2N3)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2806; Cosmic-CLP=1299081; ESTDAB=ESTDAB-083; PubMed=27087056; Technion Genomics Center; Wistar

Markers:
AmelogeninX (Wistar)
X,Y (ATCC=CRL-2806; Cosmic-CLP=1299081; ESTDAB=ESTDAB-083; PubMed=27087056; Technion Genomics Center)
CSF1PO11
D1S165612,17
D2S44111
D2S133817,24
D3S135814,16
D5S81810,12
D7S82010 (ESTDAB=ESTDAB-083)
10,12 (ATCC=CRL-2806; Cosmic-CLP=1299081; PubMed=27087056; Technion Genomics Center; Wistar)
D8S117912,14
D10S124816
D12S39118,24
D13S3178,14
D16S53912
D18S5114,15
D19S43313,15
D21S1128,29
D22S104515,16
DYS39110
FGA20,21
Penta D13
Penta E5,12
TH016,8
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; Wistar; -; https://web.archive.org/web/20141129125241/http://www.wistar.org:80/lab/meenhard-herlyn-dvm-dsc/page/melanoma-cell-lines-0
Publications

PubMed=4053039
Meenhard Herlyn, Jan Thurin, Gloria Brady Balaban-Malenbaum, Jeannette L. Bennicelli, Dorothee Herlyn, David E. Elder, Edward Bondi, DuPont Guerry 4th, Peter Carey Nowell, Wallace H. Clark Jr., Hilary Koprowski;
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Cancer Res. 45:5670-5676(1985)

PubMed=2253310; DOI=10.1007/BF00046337
Meenhard Herlyn;
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=2068080; DOI=10.1073/pnas.88.14.6028; PMCID=PMC52015
Isabelle Cornil, Dan Theodorescu, Shan Man, Meenhard Herlyn, Jadranka Adriana Jambrosic, Robert S. Kerbel;
Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.
Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991)

PubMed=8342600; PMCID=PMC1887031
Istvan Juhasz, Steven M. Albelda, David E. Elder, George Francis Murphy, Koji Adachi, Dorothee Herlyn, Istvan T. Valyi-Nagy, Meenhard Herlyn;
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice.
Am. J. Pathol. 143:528-537(1993)

PubMed=8160777; PMCID=PMC1887247
Hiroaki Kobayashi, Shan Man, John R. MacDougall, Charles H. Graham, Chao Lu, Robert S. Kerbel;
Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype.
Am. J. Pathol. 144:776-786(1994)

PubMed=11123321; DOI=10.4049/jimmunol.166.1.432
Jian Li, Sarita Pereira, Patricia Van Belle, Ping Tsui, David E. Elder, David W. Speicher, Keith Deen, Alban Linnenbach, Rajasekharan Somasundaram, Rolf K. Swoboda, Dorothee Herlyn;
Isolation of the melanoma-associated antigen p23 using antibody phage display.
J. Immunol. 166:432-438(2001)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Teresa Rodriguez, Rosa Mendez, Chrissy H. Roberts, Francisco Ruiz-Cabello Osuna, I. Anthony Dodi, Miguel Angel Lopez-Nevot, Laura Paco, Isabel Maleno, Steven G.E. Marsh, Graham Pawelec, Federico Garrido;
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer;
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688
Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith Thomas Flaherty, Marcus W. Bosenberg, Meenhard Herlyn, Katherine L. Nathanson;
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Moriah Heller Nissan, Christine A. Pratilas, Alexis M. Jones, Ricardo Ramirez, Helen Won, Cai-Lian Liu, Shakuntala Tiwari, Li Kong, Aphrothiti J. Hanrahan, Zhan Yao, Taha Merghoub ...Show all 19 authors... , Antoni Ribas, Paul B. Chapman, Rona D. Yaeger, Barry Stephen Taylor, Nikolaus Schultz, Michael F. Berger, Neal Rosen, David B. Solit; Show fewer authors
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27087056; DOI=10.1038/srep24569; PMCID=PMC4834532
Parvathi Haridas, Jacqui A. McGovern, Abhishek S. Kashyap, D.L. Sean McElwain, Matthew J. Simpson;
Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.
Sci. Rep. 6:24569-24569(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2806 - Discontinued
Coriell; WC00062 - Discontinued
Cell line databases/resources CLO; CLO_0009619
cancercelllines; CVCL_8787
Cell_Model_Passport; SIDM00973
Cosmic-CLP; 1299081
DepMap; ACH-000827
ESTDAB; ESTDAB-083
LINCS_LDP; LCL-1264
Anatomy/cell type resources BTO; BTO_0004612
Biological sample resources BioSample; SAMN03471791
BioSample; SAMN10987987
CRISP screens repositories BioGRID_ORCS_Cell_line; 343
Chemistry resources ChEMBL-Cells; CHEMBL4630605
ChEMBL-Targets; CHEMBL4630705
GDSC; 1299081
PharmacoDB; WM793_1664_2019
PubChem_Cell_line; CVCL_8787
Encyclopedic resources Wikidata; Q54994312
Experimental variables resources EFO; EFO_0002873
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM109043
GEO; GSM185202
GEO; GSM185203
GEO; GSM185204
GEO; GSM185205
GEO; GSM188235
GEO; GSM188265
GEO; GSM188324
GEO; GSM887738
GEO; GSM888833
GEO; GSM952587
GEO; GSM1670581
Polymorphism and mutation databases Cosmic; 686397
Cosmic; 886836
Cosmic; 928693
Cosmic; 972274
Cosmic; 1155266
Cosmic; 1155545
Cosmic; 1155567
Cosmic; 1238114
Cosmic; 1303078
Cosmic; 2159433
Cosmic; 2163810
IARC_TP53; 24995
LiGeA; CCLE_074
Progenetix; CVCL_8787
Proteomic databases PRIDE; PXD004343
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number43