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Cellosaurus 92-1 [Human uveal melanoma] (CVCL_8607)

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Cell line name 92-1 [Human uveal melanoma]
Synonyms 92_1; 92.1; 921
Accession CVCL_8607
Resource Identification Initiative To cite this cell line use: 92-1 [Human uveal melanoma] (RRID:CVCL_8607)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Exhibits a mesenchymal phenotype (PubMed=38601020).
Doubling time: 58 hours (PubMed=7622289); 38 hours (PubMed=24994677).
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
HLA typing Source: PubMed=28018010
Class I
HLA-AA*02:01,03:01
HLA-BB*44:02,51:01
HLA-CC*05:01,14:02
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C4PP (92.1-A)CVCL_C4PQ (92.1-B)
Originate from same individual CVCL_C300 ! 92-2 [Human uveal melanoma]
Sex of cell Female
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001441; ECACC=13012458; ESTDAB=ESTDAB-127; PubMed=22236444; PubMed=24994677; PubMed=28018010

Markers:
AmelogeninX
CSF1PO10,11
D3S135814,15
D5S8189,11 (DepMap=ACH-001441; ECACC=13012458; PubMed=22236444; PubMed=24994677)
12,13 (ESTDAB=ESTDAB-127)
D7S82010,11 (DepMap=ACH-001441; ECACC=13012458; PubMed=22236444; PubMed=24994677)
11 (ESTDAB=ESTDAB-127)
D8S117915
D13S31710,11 (ESTDAB=ESTDAB-127; PubMed=24994677)
11,12 (DepMap=ACH-001441; ECACC=13012458; PubMed=22236444)
D16S53911,12 (PubMed=22236444; PubMed=24994677)
12 (DepMap=ACH-001441; ECACC=13012458)
D18S5112,13
D21S1130
FGA21,23
Penta D9,11
Penta E12,14
TH019,9.3
TPOX8,9
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=7622289; DOI=10.1002/ijc.2910620208
Itte De Waard-Siebinga, Derk-Jan R. Blom, Marieke Griffioen, Peter I. Schrier, Ed Hoogendoorn, Geoffrey C. Beverstock, Erik H.J. Danen, Martine Johanna Jager;
Establishment and characterization of an uveal-melanoma cell line.
Int. J. Cancer 62:155-161(1995)

PubMed=15714118; DOI=10.1097/00008390-200502000-00006
Rosario Lopez-Velasco, Antonio Morilla-Grasa, Maria Antonia Saornil-Alvarez, Jose L. Ordonez, Gonzalo Blanco, Guillermo Rabano, Nieves Fernandez, Ana Almaraz;
Efficacy of five human melanocytic cell lines in experimental rabbit choroidal melanoma.
Melanoma Res. 15:29-37(2005)

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
Jason S. White, Robert L. Becker, Ian W. McLean, Alison E. Director-Myska, Joginder Nath;
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=17487557; DOI=10.1007/s10585-007-9072-z
Jean-Claude Marshall, Andre Nantel, Paula Blanco, Josee Ash, Stephanie R. Cruess, Miguel Noel Burnier Jr.;
Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors to metastasis.
Clin. Exp. Metastasis 24:353-362(2007)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131
Rosa Mendez, Natalia Aptsiauri, Ana Del Campo, Isabel Maleno, Teresa Cabrera, Francisco Ruiz-Cabello Osuna, Federico Garrido, Angel Garcia-Lora;
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Klaus Georg Griewank, Xiao-Xing Yu, Jahan S. Khalili, Mustafa Mert Sozen, Katherine Stemke-Hale, Chantale Bernatchez, Seth Wardell, Boris C. Bastian, Scott E. Woodman;
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Ken Dutton-Regester, Darryl Irwin, Priscilla Hunt, Lauren G. Aoude, Varsha Tembe, Gulietta M. Pupo, Cathy Lanagan, Candace D. Carter, Linda O'Connor, Michael O'Rourke, Richard Anthony Scolyer ...Show all 15 authors... , Graham J. Mann, Christopher W. Schmidt, Adrian Herington, Nicholas K. Hayward; Show fewer authors
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Adriana Amaro, Valentina Mirisola, Giovanna Angelini, Alessandra Musso, Francesca Isabella Tosetti, Alessia Isabella Esposito, Patrizia Perri, Francesco Baldo Lanza, Francesca Nasciuti, Carlo Mosci, Roberto Puzone ...Show all 15 authors... , Sandra Salvi, Mauro Truini, Alessandro Poggi, Ulrich Pfeffer; Show fewer authors
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, Andre Nicolas, Amaury Dumont, Guillaume Carita, Jacques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani ...Show all 14 authors... , Xavier Sastre-Garau, Didier Decaudin, Sergio Roman-Roman; Show fewer authors
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=28018010; PMCID=PMC5161001
Martine Johanna Jager, Jose Antonio Bermudez Magner, Bruce R. Ksander, Sander R. Dubovy;
Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).
Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016)

PubMed=32430489; DOI=10.1158/1535-7163.MCT-19-1016; PMCID=PMC7415561
Jessica L.F. Teh, Timothy J. Purwin, Anna Han, Vivian Chua, Prem Patel, Usman Baqai, Connie Liao, Nelisa Bechtel, Takami Sato, Michael A. Davies, Julio A. Aguirre-Ghiso, Andrew E. Aplin;
Metabolic adaptations to MEK and CDK4/6 cotargeting in uveal melanoma.
Mol. Cancer Ther. 19:1719-1726(2020)

PubMed=36164296; DOI=10.1016/j.dib.2022.108592; PMCID=PMC9508510
Xi-Feng Fei, Xiang-Tong Xie, Xiao-Yan Ji, Hai-Yan Tian, Fei Sun, Dong-Yi Jiang, Zhi-Min Wang, Qiang Huang;
Quantitative proteomic dataset of whole protein in three melanoma samples of 92.1, 92.1-A and 92.1-B.
Data Brief 45:108592.1-108592.7(2022)

PubMed=38601020; PMCID=PMC11006005
Coralie Doudnikoff, Delphine Leclerc, Gaelle Angenard, David Gilot, Cedric Coulouarn, Frederic Mouriaux;
Uveal melanoma cell lines Mel270 and 92.1 exhibit a mesenchymal phenotype and sensitivity to the cytostatic effects of transforming growth factor beta in vitro.
Mol. Vis. 30:160-166(2024)

PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024)

Cross-references
Cell line collections (Providers) ECACC; 13012458
ICLC; HTL12001
Cell line databases/resources CLDB; cl7221
cancercelllines; CVCL_8607
DepMap; ACH-001441
ESTDAB; ESTDAB-127
Encyclopedic resources Wikidata; Q54605663
Experimental variables resources EFO; EFO_0022503
Gene expression databases GEO; GSM276761
Polymorphism and mutation databases Cosmic; 848328
Cosmic; 899893
Cosmic; 916137
Cosmic; 986619
Cosmic; 1320371
Cosmic; 1628394
Cosmic; 1669117
Cosmic; 2036703
Cosmic; 2163829
Proteomic databases PRIDE; PXD032215
PRIDE; PXD051055
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number39