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Cellosaurus Hu1734 (CVCL_8451)

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Cell line name Hu1734
Synonyms Hu 1734; HU 1734
Accession CVCL_8451
Resource Identification Initiative To cite this cell line use: Hu1734 (RRID:CVCL_8451)
Comments Problematic cell line: Contaminated. Shown to be a HCV-29 derivative (PubMed=7905254; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00128.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly469Val (c.1406G>T); ClinVar=VCV000044803; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:12362; TSC1; Simple; p.Gln55Ter (c.163C>T); ClinVar=VCV000048808; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8228 (HCV-29)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=7905254
Britta Christensen, Claus Hansen, Jorgen Kieler, Jacqueline Schmidt;
Identity of non-malignant human urothelial cell lines classified as transformation grade I (TGrI) and II (TGrII).
Anticancer Res. 13:2187-2191(1993)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8451
Biological sample resources BioSample; SAMN03151654
Encyclopedic resources Wikidata; Q54896693
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27