Cellosaurus logo
expasy logo

Cellosaurus PT45-P1res (CVCL_8409)

[Text][XML][JSON]
Cell line name PT45-P1res
Accession CVCL_8409
Resource Identification Initiative To cite this cell line use: PT45-P1res (RRID:CVCL_8409)
Comments Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Unspecified (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8408 (PT45-P1)
Category Cancer cell line
Publications

PubMed=16474845; DOI=10.1038/sj.onc.1209423
Susanne Sebens Muerkoster, J. Lust, Alexander Arlt, Robert Hasler, Maike Witt, Thorsten Sebens, Stefan Schreiber, Ulrich Robert Folsch, Heiner Schafer;
Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1beta and NO lead to inactivation of caspases.
Oncogene 25:3973-3981(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8409
Encyclopedic resources Wikidata; Q54948656
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number16