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Cellosaurus HSC-3-M3 (CVCL_8323)

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Cell line name HSC-3-M3
Accession CVCL_8323
Resource Identification Initiative To cite this cell line use: HSC-3-M3 (RRID:CVCL_8323)
Comments Population: Japanese.
Characteristics: Has lymph node metastatizing potential. Established from a xenograft obtained by injection of the parent cell line in the tongue of BALB/c nude mice.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu120Ter (c.358G>T); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Gly (c.1634A>G); ClinVar=VCV000013656; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys305fs (c.912_913insTAAG); Zygosity=Unspecified (from parent cell line).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1288 (HSC-3)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1354

Markers:
AmelogeninX,Y
CSF1PO11
D5S81811,13
D7S82013
D13S31712
D16S5399
TH016,9.3
TPOX8
vWA14,17

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Publications

PubMed=9813718; DOI=10.1016/S1368-8375(98)80003-1
Takeshi Matsui, Takahide Ota, Yoshimichi Ueda, Mikio Tanino, Shizuo Odashima;
Isolation of a highly metastatic cell line to lymph node in human oral squamous cell carcinoma by orthotopic implantation in nude mice.
Oral Oncol. 34:253-256(1998)

Cross-references
Cell line collections (Providers) JCRB; JCRB1354
JCRB; NIHS0589 - Discontinued
Encyclopedic resources Wikidata; Q54896386
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number18