ID   HSC-3-M3
AC   CVCL_8323
DR   JCRB; JCRB1354
DR   JCRB; NIHS0589
DR   Wikidata; Q54896386
RX   PubMed=9813718;
CC   Population: Japanese.
CC   Characteristics: Has lymph node metastatizing potential. Established from a xenograft obtained by injection of the parent cell line in the tongue of BALB/c nude mice.
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu120Ter (c.358G>T); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Gly (c.1634A>G); ClinVar=VCV000013656; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys305fs (c.912_913insTAAG); Zygosity=Unspecified (from parent cell line).
CC   Discontinued: JCRB; NIHS0589; true.
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
ST   Source(s): JCRB=JCRB1354
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 9
ST   D5S818: 11,13
ST   D7S820: 13
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1288 ! HSC-3
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 17
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RX   PubMed=9813718; DOI=10.1016/S1368-8375(98)80003-1;
RA   Matsui T., Ota T., Ueda Y., Tanino M., Odashima S.;
RT   "Isolation of a highly metastatic cell line to lymph node in human
RT   oral squamous cell carcinoma by orthotopic implantation in nude
RT   mice.";
RL   Oral Oncol. 34:253-256(1998).
//