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Cellosaurus KK47 (CVCL_8253)

[Text version]
Cell line name KK47
Synonyms KK-47
Accession CVCL_8253
Resource Identification Initiative To cite this cell line use: KK47 (RRID:CVCL_8253)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Part of: UBC-40 urothelial bladder cancer cell line index.
Population: Japanese.
Doubling time: 23.5 hours (PubMed=470258); 27 hours (PubMed=1353119).
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8254 (KK47/ADM)CVCL_8255 (KK47/DDP10)CVCL_8256 (KK47/DDP20)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): TKG=TKG 0663

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12,13
D7S8208,12
D13S31712,13.3
D16S5399,10
TH017
TPOX12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=604596; DOI=10.5980/jpnjurol1928.68.11_1003
Tadashi Taya, Tetsuji Kobayashi, Kenji Tsukahara, Tadao Uchibayashi, Katsusuke Naito, Haruo Hisazumi, Kyoichi Kuroda;
In vitro culture of malignant tumor tissues from the human urinary tract.
Nihon Hinyokika Gakkai Zasshi 68:1003-1010(1977)

PubMed=470258; DOI=10.5980/jpnjurol1928.70.5_485
Haruo Hisazumi, Mototsugu Kanokogi, Kazuyoshi Nakajima, Tetsuji Kobayashi, Kenji Tsukahara, Katsusuke Naito, Kyoichi Kuroda, Fujitsugu Matsubara;
Established cell line of urinary bladder carcinoma (KK-47): growth, heterotransplantation, microscopic structure and chromosome pattern.
Nihon Hinyokika Gakkai Zasshi 70:485-494(1979)

PubMed=6244232
Richard D. Williams;
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=6620776; DOI=10.5980/jpnjurol1928.74.5_704
Hisashi Koizumi;
Chemosensitivity of KK-47 bladder cancer cells and KN-41 renal cancer cells heterotransplanted in nude mice.
Nihon Hinyokika Gakkai Zasshi 74:704-718(1983)

PubMed=3708594
John R.W. Masters, Peter J. Hepburn, Lawrence Walker, Wilma J. Highman, Ludwik K. Trejdosiewicz, Susan Povey, Mohamed Parkar, Bridget T. Hill, Peter N. Riddle, Leonard Maurice Franks;
Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.
Cancer Res. 46:3630-3636(1986)

PubMed=1353119; DOI=10.1016/S0022-5347(17)36624-7
Kohichi Kimiya, Seiji Naito, Tsukasa Soejima, Naotaka Sakamoto, Shuji Kotoh, Joichi Kumazawa, Takashi Tsuruo;
Establishment and characterization of doxorubicin-resistant human bladder cancer cell line, KK47/ADM.
J. Urol. 148:441-445(1992)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Yves Allory, Willemien Beukers, Ana Sagrera, Marta Flandez, Miriam Marques, Mirari Marquez, Kirstin A. van der Keur, Lars Dyrskjot, Irene Lurkin, Marcel Vermeij, Alfredo Carrato ...Show all 24 authors... , Josep Lloreta, Jose A. Lorente, Enrique Carrillo-de-Santa-Pau, Roy G. Masius, Manolis Kogevinas, Ewout Willem Steyerberg, Angela A.G. van Tilborg, Cheno Abas, Torben Falck Orntoft, Tahlita C.M. Zuiverloon, Nuria Malats, Ellen C. Zwarthoff, Francisco X. Real; Show fewer authors
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) TKG; TKG 0663 - Discontinued
Cell line databases/resources cancercelllines; CVCL_8253
Anatomy/cell type resources BTO; BTO_0003552
Chemistry resources ChEMBL-Cells; CHEMBL3308615
ChEMBL-Targets; CHEMBL614674
PubChem_Cell_line; CVCL_8253
Encyclopedic resources Wikidata; Q54899980
Experimental variables resources EFO; EFO_0022544
Gene expression databases GEO; GSM136247
GEO; GSM492492
GEO; GSM1374600
GEO; GSM1574547
Polymorphism and mutation databases Cosmic; 925824
Cosmic; 2037949
Progenetix; CVCL_8253
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number30