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Cellosaurus HANK1 (CVCL_8226)

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Cell line name HANK1
Synonyms HANK-1; HANK
Accession CVCL_8226
Resource Identification Initiative To cite this cell line use: HANK1 (RRID:CVCL_8226)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 3 days (PubMed=9858215).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: CNV analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Retroperitoneal lymph node; UBERON=UBERON_0035371.
Cell type: NK T-cell; CL=CL_0000814.
Disease Nasal type extranodal NK/T-cell lymphoma (NCIt: C4684)
Extranodal nasal NK/T cell lymphoma (ORDO: Orphanet_86879)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line

PubMed=9858215; DOI=10.1046/j.1365-2141.1998.01029.x
Kagami Y., Nakamura S., Suzuki R., Iida S., Yatabe Y., Okada Y., Kobayashi T., Tsurumi T., Seto M., Ogura M., Taguchi O., Morishima Y.
Establishment of an IL-2-dependent cell line derived from 'nasal-type' NK/T-cell lymphoma of CD2+, sCD3-, CD3epsilon+, CD56+ phenotype and associated with the Epstein-Barr virus.
Br. J. Haematol. 103:669-677(1998)

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x
Liu A., Takakuwa T., Luo W.-J., Fujita S., Aozasa K.
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=19194464; DOI=10.1038/leu.2009.3
Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H., Klinkebiel D., Christman J.K., Patel K., Cao K., Shen L., Dybkaer K., Tsui I.F.L., Ali H., Shimizu N., Au W.Y., Lam W.L., Chan W.C.
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K., Vose J.M., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H., Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.C.
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

Cell line databases/resources cancercelllines; CVCL_8226
Encyclopedic resources Wikidata; Q54872411
Gene expression databases GEO; GSM471997
GEO; GSM3021081
Polymorphism and mutation databases Cosmic; 1534876
Cosmic; 1542076
Cosmic; 2025322
Progenetix; CVCL_8226
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number17