Cellosaurus logo
expasy logo

Cellosaurus HANK1 (CVCL_8226)

[Text version]
Cell line name HANK1
Synonyms HANK-1; HANK
Accession CVCL_8226
Resource Identification Initiative To cite this cell line use: HANK1 (RRID:CVCL_8226)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 3 days (PubMed=9858215).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Derived from site: In situ; Retroperitoneal lymph node; UBERON=UBERON_0035371.
Cell type: NK T-cell; CL=CL_0000814.
Disease Nasal type extranodal NK/T-cell lymphoma (NCIt: C4684)
Extranodal nasal NK/T cell lymphoma (ORDO: Orphanet_86879)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=9858215; DOI=10.1046/j.1365-2141.1998.01029.x
Yoshitoyo Kagami, Shigeo Nakamura, Ritsurou Suzuki, Shinsuke Iida, Yasushi Yatabe, Yasutaka Okada, Tomoko Kobayashi, Tatsuya Tsurumi, Masao Seto, Michinori Ogura, Osamu Taguchi, Yasuo Morishima;
Establishment of an IL-2-dependent cell line derived from 'nasal-type' NK/T-cell lymphoma of CD2+, sCD3-, CD3epsilon+, CD56+ phenotype and associated with the Epstein-Barr virus.
Br. J. Haematol. 103:669-677(1998)

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954
Angen Liu, Tetsuya Takakuwa, Wen-Juan Luo, Shigeki Fujita, Katsuyuki Aozasa;
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=19194464; DOI=10.1038/leu.2009.3
Javeed Iqbal, Can Kucuk, Ronald J. Deleeuw, Gopesh Srivastava, Wayne Tam, Hui-Min Geng, David L. Klinkebiel, Judith K. Christman, Kavita N. Patel, K. Cao, L. Shen ...Show all 18 authors... , Karen Dybkaer, Ivy F.L. Tsui, Hesham H. Ali, N. Shimizu, Wing Yan Au, Wan L. Lam, Wing-Chung Chan; Show fewer authors
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Javeed Iqbal, Dennis D. Weisenburger, Aparajita Chowdhury, Ming-Ying Tsai, Gopesh Srivastava, Timothy Charles Greiner, Can Kucuk, Karen E. Deffenbacher, Julie Marie Vose, L. Smith, Wing Yan Au ...Show all 22 authors... , Shigeo Nakamura, Masao Seto, Jan Delabie, Francoise Berger, Florence Loong, Young-Hyeh Ko, Ivy Sng, X. Liu, Thomas P. Loughran Jr., James Olen Armitage, Wing-Chung Chan; Show fewer authors
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8226
Encyclopedic resources Wikidata; Q54872411
Gene expression databases GEO; GSM471997
GEO; GSM3021081
Polymorphism and mutation databases Cosmic; 1534876
Cosmic; 1542076
Cosmic; 2025322
Progenetix; CVCL_8226
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number18