ID   HANK1
AC   CVCL_8226
SY   HANK-1; HANK
DR   cancercelllines; CVCL_8226
DR   Cosmic; 1534876
DR   Cosmic; 1542076
DR   Cosmic; 2025322
DR   GEO; GSM471997
DR   GEO; GSM3021081
DR   Progenetix; CVCL_8226
DR   Wikidata; Q54872411
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=9858215;
RX   PubMed=10803505;
RX   PubMed=16827800;
RX   PubMed=19194464;
RX   PubMed=21052088;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Doubling time: 3 days (PubMed=9858215).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Derived from site: In situ; Retroperitoneal lymph node; UBERON=UBERON_0035371.
CC   Cell type: NK T-cell; CL=CL_0000814.
DI   NCIt; C4684; Nasal type extranodal NK/T-cell lymphoma
DI   ORDO; Orphanet_86879; Extranodal nasal NK/T cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 18
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=9858215; DOI=10.1046/j.1365-2141.1998.01029.x;
RA   Kagami Y., Nakamura S., Suzuki R., Iida S., Yatabe Y., Okada Y.,
RA   Kobayashi T., Tsurumi T., Seto M., Ogura M., Taguchi O., Morishima Y.;
RT   "Establishment of an IL-2-dependent cell line derived from 'nasal-type'
RT   NK/T-cell lymphoma of CD2+, sCD3-, CD3epsilon+, CD56+ phenotype and
RT   associated with the Epstein-Barr virus.";
RL   Br. J. Haematol. 103:669-677(1998).
//
RX   PubMed=10803505; DOI=10.1038/sj.leu.2401778;
RA   Drexler H.G., Matsuo Y.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   natural killer cell leukemia-lymphoma.";
RL   Leukemia 14:777-782(2000).
//
RX   PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954;
RA   Liu A., Takakuwa T., Luo W.-J., Fujita S., Aozasa K.;
RT   "Alterations in ATR in nasal NK/T-cell lymphoma and chronic active
RT   Epstein-Barr virus infection.";
RL   Cancer Sci. 97:605-610(2006).
//
RX   PubMed=19194464; DOI=10.1038/leu.2009.3;
RA   Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H.-M.,
RA   Klinkebiel D.L., Christman J.K., Patel K.N., Cao K., Shen L., Dybkaer K.,
RA   Tsui I.F.L., Ali H.H., Shimizu N., Au W.Y., Lam W.L., Chan W.-C.;
RT   "Genomic analyses reveal global functional alterations that promote
RT   tumor growth and novel tumor suppressor genes in natural killer-cell
RT   malignancies.";
RL   Leukemia 23:1139-1151(2009).
//
RX   PubMed=21052088; DOI=10.1038/leu.2010.255;
RA   Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.-Y., Srivastava G.,
RA   Greiner T.C., Kucuk C., Deffenbacher K.E., Vose J.M., Smith L., Au W.Y.,
RA   Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H.,
RA   Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.-C.;
RT   "Natural killer cell lymphoma shares strikingly similar molecular
RT   features with a group of non-hepatosplenic gammadelta T-cell lymphoma
RT   and is highly sensitive to a novel aurora kinase A inhibitor in
RT   vitro.";
RG   International Peripheral T-cell Lymphoma Project;
RL   Leukemia 25:348-358(2011).
//