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Cellosaurus G-415 (CVCL_8198)

[Text version]

Cell line name G-415
Synonyms G415
Accession CVCL_8198
Resource Identification Initiative To cite this cell line use: G-415 (RRID:CVCL_8198)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 48 hours, at 30th passage (PubMed=7429092); 30 hours (PubMed=32293552).
Omics: Deep RNAseq analysis.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (DepMap).
Disease Gallbladder carcinoma (NCIt: C3844)
Carcinoma of gallbladder and extrahepatic biliary tract (ORDO: Orphanet_56044)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): DepMap; RCB; TKG

Markers:
AmelogeninX
CSF1PO12
D3S135815,17
D5S81812
D7S82011,12
D8S117912,14
D13S3178,10
D16S53912 (TKG)
9,12 (DepMap; RCB)
D18S5112,14
D21S1132.2
FGA21,24
Penta D9
Penta E12,14
TH017
TPOX11
vWA15,16 (TKG)
16 (DepMap; RCB)

Run an STR similarity search on this cell line
Publications

PubMed=7429092; DOI=10.20772/cancersci1959.71.4_574
Koyama S., Yoshioka T., Mizushima A., Kawakita I., Yamagata S., Fukutomi H., Sakita T., Kondo I., Kikuchi M.
Establishment of a cell line (G-415) from a human gallbladder carcinoma.
Gann 71:574-575(1980)

PubMed=11713577; DOI=10.3892/ijo.19.6.1099
Jiao W., Miyazaki K., Kitajima Y.
Exogenous expression of E-cadherin in gallbladder carcinoma cell line G-415 restores its cellular polarity and differentiation.
Int. J. Oncol. 19:1099-1107(2001)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=32293552; DOI=10.1186/s40659-020-00282-7
Garcia P., Bizama C., Rosa L., Espinoza J.A., Weber H., Cerda-Infante J., Sanchez M., Montecinos V.P., Lorenzo-Bermejo J., Boekstegers F., Davila-Lopez M., Alfaro F., Leiva-Acevedo C., Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Biol. Res. 53:13.1-13.17(2020)

PubMed=32899426; DOI=10.3390/cancers12092510
Scherer D., Davila Lopez M., Goeppert B., Abrahamsson S., Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D., Umu S.U., Rounge T.B., Roessler S., Bermejo J.L.
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

Cross-references
Cell line collections RCB; RCB2640
TKG; TKG 0642
Cell line databases/resources CLO; CLO_0050017
Cell_Model_Passport; SIDM01807
DepMap; ACH-001850
Biological sample resources BioSample; SAMN03471927
Encyclopedic resources Wikidata; Q54835351
Polymorphism and mutation databases Cosmic; 2674060
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number19