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Cellosaurus G-415 (CVCL_8198)

[Text version]
Cell line name G-415
Synonyms G415
Accession CVCL_8198
Resource Identification Initiative To cite this cell line use: G-415 (RRID:CVCL_8198)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 48 hours (Note=At 30th passage) (PubMed=7429092); 30 hours (PubMed=32293552).
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (DepMap=ACH-001850).
Disease Gallbladder carcinoma (NCIt: C3844)
Carcinoma of gallbladder and extrahepatic biliary tract (ORDO: Orphanet_56044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001850; RCB=RCB2640; TKG=TKG 0642

Markers:
AmelogeninX
CSF1PO12
D3S135815,17
D5S81812
D7S82011,12
D8S117912,14
D13S3178,10
D16S5399,12 (DepMap=ACH-001850; RCB=RCB2640)
12 (TKG=TKG 0642)
D18S5112,14
D21S1132.2
FGA21,24
Penta D9
Penta E12,14
TH017
TPOX11
vWA15,16 (TKG=TKG 0642)
16 (DepMap=ACH-001850; RCB=RCB2640)

Run an STR similarity search on this cell line
Publications

PubMed=7429092; DOI=10.20772/cancersci1959.71.4_574
Shohei Koyama, Takayuki Yoshioka, Atsushi Mizushima, Isao Kawakita, Susumu Yamagata, Hisayuki Fukutomi, Takao Sakita, Ikuko Kondo, Masanori Kikuchi;
Establishment of a cell line (G-415) from a human gallbladder carcinoma.
Gann 71:574-575(1980)

PubMed=11713577; DOI=10.3892/ijo.19.6.1099
Wan Jiao, Kohji Miyazaki, Yoshihiko Kitajima;
Exogenous expression of E-cadherin in gallbladder carcinoma cell line G-415 restores its cellular polarity and differentiation.
Int. J. Oncol. 19:1099-1107(2001)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737
Supriya Kumar Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon ...Show all 28 authors... , Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram Francis Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina Rosa Ferrone, Andrew Xiu-Xuan Zhu, Jae Keith Joung, Kevan Michael Shokat, Cyril Henri Benes, Nabeel M. Bardeesy; Show fewer authors
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=32293552; DOI=10.1186/s40659-020-00282-7; PMCID=PMC7158131
Patricia Garcia, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sanchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Davila-Lopez ...Show all 19 authors... , Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato, Pamela Leal, Marcela Lagos, Juan Carlos Roa; Show fewer authors
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Biol. Res. 53:13.1-13.17(2020)

PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451
Dominique Scherer, Marcela Davila-Lopez, Benjamin Goeppert, Sanna Abrahamsson, Rosa Gonzalez Silos, Igor Nova, Katherine Marcelain, Juan Carlos Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge ...Show all 13 authors... , Stephanie Roessler, Justo Lorenzo-Bermejo; Show fewer authors
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line collections (Providers) RCB; RCB2640
TKG; TKG 0642
Cell line databases/resources CLO; CLO_0050017
cancercelllines; CVCL_8198
Cell_Model_Passport; SIDM01807
DepMap; ACH-001850
Biological sample resources BioSample; SAMN03471927
Encyclopedic resources Wikidata; Q54835351
Polymorphism and mutation databases Cosmic; 2674060
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25