ID   G-415
AC   CVCL_8198
SY   G415
DR   CLO; CLO_0050017
DR   BioSample; SAMN03471927
DR   cancercelllines; CVCL_8198
DR   Cell_Model_Passport; SIDM01807
DR   Cosmic; 2674060
DR   DepMap; ACH-001850
DR   RCB; RCB2640
DR   TKG; TKG 0642
DR   Wikidata; Q54835351
RX   PubMed=7429092;
RX   PubMed=11713577;
RX   PubMed=27231123;
RX   PubMed=32293552;
RX   PubMed=32899426;
RX   PubMed=39026794;
CC   Part of: Biliary tract cancer cell line atlas.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Doubling time: 48 hours (Note=At 30th passage) (PubMed=7429092); 30 hours (PubMed=32293552).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (DepMap=ACH-001850).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): DepMap=ACH-001850; RCB=RCB2640; TKG=TKG 0642
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,10
ST   D16S539: 9,12 (DepMap=ACH-001850; RCB=RCB2640)
ST   D16S539: 12 (TKG=TKG 0642)
ST   D18S51: 12,14
ST   D21S11: 32.2
ST   D3S1358: 15,17
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 21,24
ST   Penta D: 9
ST   Penta E: 12,14
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 15,16 (TKG=TKG 0642)
ST   vWA: 16 (DepMap=ACH-001850; RCB=RCB2640)
DI   NCIt; C3844; Gallbladder carcinoma
DI   ORDO; Orphanet_56044; Carcinoma of gallbladder and extrahepatic biliary tract
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   68Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=7429092; DOI=10.20772/cancersci1959.71.4_574;
RA   Koyama S., Yoshioka T., Mizushima A., Kawakita I., Yamagata S.,
RA   Fukutomi H., Sakita T., Kondo I., Kikuchi M.;
RT   "Establishment of a cell line (G-415) from a human gallbladder
RT   carcinoma.";
RL   Gann 71:574-575(1980).
//
RX   PubMed=11713577; DOI=10.3892/ijo.19.6.1099;
RA   Jiao W., Miyazaki K., Kitajima Y.;
RT   "Exogenous expression of E-cadherin in gallbladder carcinoma cell line
RT   G-415 restores its cellular polarity and differentiation.";
RL   Int. J. Oncol. 19:1099-1107(2001).
//
RX   PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442; PMCID=PMC5458737;
RA   Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C.,
RA   Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K.,
RA   Greninger P., McDermott U., Garnett M.J., Jenkins R.L.,
RA   Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y.,
RA   Goyal L., Ferrone C.R., Zhu A.X.-X., Joung J.K., Shokat K.M., Benes C.H.,
RA   Bardeesy N.M.;
RT   "Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity
RT   and SRC dependence in intrahepatic cholangiocarcinoma.";
RL   Cancer Discov. 6:727-739(2016).
//
RX   PubMed=32293552; DOI=10.1186/s40659-020-00282-7; PMCID=PMC7158131;
RA   Garcia P., Bizama C., Rosa L., Espinoza J.A., Weber H.,
RA   Cerda-Infante J., Sanchez M., Montecinos V.P., Lorenzo-Bermejo J.,
RA   Boekstegers F., Davila-Lopez M., Alfaro F., Leiva-Acevedo C.,
RA   Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.;
RT   "Functional and genomic characterization of three novel cell lines
RT   derived from a metastatic gallbladder cancer tumor.";
RL   Biol. Res. 53:13.1-13.17(2020).
//
RX   PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451;
RA   Scherer D., Davila-Lopez M., Goeppert B., Abrahamsson S.,
RA   Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D.,
RA   Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.;
RT   "RNA sequencing of hepatobiliary cancer cell lines: data and
RT   applications to mutational and transcriptomic profiling.";
RL   Cancers (Basel) 12:2510.1-2510.14(2020).
//
RX   PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448;
RA   Vijay V., Karisani N., Shi L., Hung Y.-H., Vu P., Kattel P., Kenney L.,
RA   Merritt J., Adil R., Wu Q.-B., Zhen Y.-L., Morris R., Kreuzer J.,
RA   Kathiresan M., Herrera Lopez X.I., Ellis H., Gritti I.G., Lecorgne L.,
RA   Farag I., Popa A., Shen W., Kato H., Xu Q., Balasooriya E.R., Wu M.-J.,
RA   Chaturantabut S., Kelley R.K., Cleary J.M., Lawrence M.S., Root D.E.,
RA   Benes C.H., Deshpande V., Juric D., Sellers W.R., Ferrone C.R., Haas W.,
RA   Vazquez F., Getz G., Bardeesy N.M.;
RT   "Generation of a biliary tract cancer cell line atlas reveals
RT   molecular subtypes and therapeutic targets.";
RL   bioRxiv 2024:07.04.601970-07.04.601970(2024).
//