Cellosaurus cell line Detroit 98/AH-R (CVCL

Cellosaurus Detroit 98/AH-R (CVCL_8191)

Cross-references
Cell line name	Detroit 98/AH-R
Synonyms	Det98/AH-R; Det98/AHR; D98/AH-R
Accession	CVCL_8191
Resource Identification Initiative	To cite this cell line use: Detroit 98/AH-R (RRID:CVCL_8191)
Comments	Problematic cell line: Contaminated. Ancestral cell line (Detroit 98) has been shown to be a HeLa derivative (PubMed=566722; PubMed=1246601; PubMed=20143388). Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00021. Population: African American. Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine. Selected for resistance to: ChEBI; CHEBI_136532; 8-azahypoxanthine. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_U961 (Detroit 98/AH)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	CLPUB00640 Waclaw Szybalski, Elizabeth Hunter Szybalska, Giorgio Ragni; Genetic studies with human cell lines. Natl. Cancer Inst. Monogr. 7:75-89(1962) PubMed=13980043; DOI=10.1073/pnas.48.12.2026; PMCID=PMC221117 Elizabeth Hunter Szybalska, Waclaw Szybalski; Genetics of human cell line. IV. DNA-mediated heritable transformation of a biochemical trait. Proc. Natl. Acad. Sci. U.S.A. 48:2026-2034(1962) PubMed=14278461; DOI=10.1101/sqb.1964.029.01.019 Waclaw Szybalski; Chemical reactivity of chromosomal DNA as related to mutagenicity: studies with human cell lines. Cold Spring Harb. Symp. Quant. Biol. 29:151-159(1964) DOI=10.1007/BF02618370 Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon; The animal cell culture collection. In Vitro 5:1-16(1970) PubMed=1246601; DOI=10.1126/science.1246601 Walter Anthony Nelson-Rees, Robert R. Flandermeyer; HeLa cultures defined. Science 191:96-98(1976) PubMed=566722; DOI=10.1007/BF02616110 Kantharajapura Subbegowda Lavappa; Survey of ATCC stocks of human cell lines for HeLa contamination. In Vitro 14:469-475(1978) PubMed=20143388; DOI=10.1002/ijc.25242 Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney; Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Cell line collections (Providers)	ATCC; CCL-18.4 - Discontinued
Biological sample resources	BioSample; SAMN03151683
Encyclopedic resources	Wikidata; Q54831010
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	25