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Cellosaurus Detroit 98/AH-2 (CVCL_8190)

[Text version]
Cell line name Detroit 98/AH-2
Synonyms Det98/AH-2; D98/AH-2; D98-AH2
Accession CVCL_8190
Resource Identification Initiative To cite this cell line use: Detroit 98/AH-2 (RRID:CVCL_8190)
Comments Problematic cell line: Contaminated. Ancestral cell line (Detroit 98) has been shown to be a HeLa derivative (PubMed=566722; PubMed=1246601; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00020.
Population: African American.
Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
Selected for resistance to: ChEBI; CHEBI:136532; 8-azahypoxanthine.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Misspelling: Detroit 98/AT-2; PubMed=1246601.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8189 (Detroit 98/AG)
CVCL_2884 (D98/AH2 Clone B)CVCL_X203 (D98/HR-1)CVCL_C8NZ (ESH5)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): RCB=RCB2105; TKG=TKG 0191

CSF1PO9,10 (TKG=TKG 0191)
9,10,11 (RCB=RCB2105)

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=13980043; DOI=10.1073/pnas.48.12.2026
Szybalska E.H., Szybalski W.
Genetics of human cell line. IV. DNA-mediated heritable transformation of a biochemical trait.
Proc. Natl. Acad. Sci. U.S.A. 48:2026-2034(1962)

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=1246601; DOI=10.1126/science.1246601
Nelson-Rees W.A., Flandermeyer R.R.
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=566722; DOI=10.1007/BF02616110
Lavappa K.S.
Survey of ATCC stocks of human cell lines for HeLa contamination.
In Vitro 14:469-475(1978)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections (Providers) ATCC; CCL-18.3 - Discontinued
RCB; RCB2105
TKG; TKG 0191
Biological sample resources BioSample; SAMN03151682
BioSample; SAMN03472006
Encyclopedic resources Wikidata; Q54831009
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25