ID   Detroit 98/AH-2
AC   CVCL_8190
SY   Det98/AH-2; D98/AH-2; D98-AH2
DR   ATCC; CCL-18.3
DR   BioSample; SAMN03151682
DR   BioSample; SAMN03472006
DR   FANTOM5_SSTAR; 10552-107I3
DR   RCB; RCB2105
DR   TKG; TKG 0191
DR   Wikidata; Q54831009
RX   DOI=10.1007/BF02618370;
RX   PubMed=566722;
RX   PubMed=1246601;
RX   PubMed=13980043;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Ancestral cell line (Detroit 98) has been shown to be a HeLa derivative (PubMed=566722; PubMed=1246601; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00020.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine.
CC   Selected for resistance to: ChEBI; CHEBI_136532; 8-azahypoxanthine.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Misspelling: Detroit 98/AT-2; PubMed=1246601.
CC   Discontinued: ATCC; CCL-18.3; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): RCB=RCB2105; TKG=TKG 0191
ST   Amelogenin: X
ST   CSF1PO: 9,10 (TKG=TKG 0191)
ST   CSF1PO: 9,10,11 (RCB=RCB2105)
ST   D13S317: 13.3
ST   D16S539: 9,10
ST   D5S818: 11,12
ST   D7S820: 12
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8189 ! Detroit 98/AG
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 27
CH   CVCL_2884 ! D98/AH2 Clone B
CH   CVCL_X203 ! D98/HR-1
CH   CVCL_C8NZ ! ESH5
//
RX   PubMed=13980043; DOI=10.1073/pnas.48.12.2026; PMCID=PMC221117;
RA   Szybalska, Elizabeth Hunter
RA   Szybalski, Waclaw
RT   "Genetics of human cell line. IV. DNA-mediated heritable
RT   transformation of a biochemical trait.";
RL   Proc. Natl. Acad. Sci. U.S.A. 48:2026-2034(1962).
//
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees, Walter Anthony
RA   Flandermeyer, Robert R.
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg, Cyril S.
RA   Coriell, Lewis Lemon
RA   Kniazeff, Alexis John
RA   Shannon, John E.
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=566722; DOI=10.1007/BF02616110;
RA   Lavappa, Kantharajapura Subbegowda
RT   "Survey of ATCC stocks of human cell lines for HeLa contamination.";
RL   In Vitro 14:469-475(1978).
//