Cellosaurus cell line CSM14.1 (CVCL

Cellosaurus CSM14.1 (CVCL_8182)

Cross-references
Cell line name	CSM14.1
Synonyms	CSM 14.1
Accession	CVCL_8182
Resource Identification Initiative	To cite this cell line use: CSM14.1 (RRID:CVCL_8182)
Comments	Characteristics: Proliferates at 33 Celsius and displays flat morphology. At 39 Celsius the cells stop dividing and some cells change from flat cells with broad processes to neuron-like morphology (CelloPub=CLPUB00032). Characteristics: Can be differentiated in vitro into tyrosine hydroxylase (TH) and aldehyde-dehydrogenase 2-containing neurons (PubMed=12171477). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Omics: Proteomics; 2DE-MS. Derived from site: In situ; Embryonic brain, mesencephalon; UBERON=UBERON_0009616.
Species of origin	Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Sex of cell	Sex unspecified
Age at sampling	14FD
Category	Conditionally immortalized cell line
Publications	CLPUB00032 Michele M. Durand, Diane C. Chugani, Mahmoud Mahmoudi, Michael Edward Phelps; Characterization of neuron-like cell line immortalized from primary rat mesencephalon cultures. Soc. Neurosci. Abstr. 16:40-40(1990) PubMed=12171477; DOI=10.1046/j.1469-7580.2002.00072.x; PMCID=PMC1570893 Stefan Jean-Pierre Haas, Andreas Wree; Dopaminergic differentiation of the Nurr1-expressing immortalized mesencephalic cell line CSM14.1 in vitro. J. Anat. 201:61-69(2002) PubMed=17203489; DOI=10.1002/jnr.21170 Stefan Jean-Pierre Haas, Stephan Beckmann, Stanislav Petrov, Christian Andressen, Andreas Wree, Oliver Schmitt; Transplantation of immortalized mesencephalic progenitors (CSM14.1 cells) into the neonatal parkinsonian rat caudate putamen. J. Neurosci. Res. 85:778-786(2007) PubMed=22863662; DOI=10.1111/j.1582-4934.2012.01607.x; PMCID=PMC4118228 Asir Alwin Prem Anand, S. Gowri Sankar, Kokila V. Vani; Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons. J. Cell. Mol. Med. 16:2592-2610(2012) PubMed=24592386; DOI=10.1155/2014/351821; PMCID=PMC3925624 B. Weiss, Stefan Jean-Pierre Haas, Grit Lessner, Stefan Mikkat, Michael Kreutzer, Michael O. Glocker, Andreas Wree, Oliver Schmitt; The proteome of the differentiating mesencephalic progenitor cell line CSM14.1 in vitro. BioMed Res. Int. 2014:351821.1-351821.13(2014)
Cell line databases/resources	TOKU-E; 4009
Anatomy/cell type resources	BTO; BTO_0004073
Encyclopedic resources	Wikidata; Q54814665
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	15