ID   CSM14.1
AC   CVCL_8182
SY   CSM 14.1
DR   BTO; BTO_0004073
DR   TOKU-E; 4009
DR   Wikidata; Q54814665
RX   CelloPub=CLPUB00032;
RX   PubMed=12171477;
RX   PubMed=17203489;
RX   PubMed=24592386;
CC   Characteristics: Proliferates at 33 Celsius and displays flat morphology. At 39 Celsius the cells stop dividing and some cells change from flat cells with broad processes to neuron-like morphology (CelloPub=CLPUB00032).
CC   Characteristics: Can be differentiated in vitro into tyrosine hydroxylase (TH) and aldehyde-dehydrogenase 2-containing neurons (PubMed=12171477).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Proteomics; 2DE-MS.
CC   Derived from site: In situ; Embryonic brain, mesencephalon; UBERON=UBERON_0009616.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   14FD
CA   Conditionally immortalized cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 14
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RX   CelloPub=CLPUB00032;
RA   Durand M.M., Chugani D.C., Mahmoudi M., Phelps M.E.;
RT   "Characterization of neuron-like cell line immortalized from primary
RT   rat mesencephalon cultures.";
RL   Soc. Neurosci. Abstr. 16:40-40(1990).
//
RX   PubMed=12171477; DOI=10.1046/j.1469-7580.2002.00072.x; PMCID=PMC1570893;
RA   Haas S.J.-P., Wree A.;
RT   "Dopaminergic differentiation of the Nurr1-expressing immortalized
RT   mesencephalic cell line CSM14.1 in vitro.";
RL   J. Anat. 201:61-69(2002).
//
RX   PubMed=17203489; DOI=10.1002/jnr.21170;
RA   Haas S.J.-P., Beckmann S., Petrov S., Andressen C., Wree A.,
RA   Schmitt O.;
RT   "Transplantation of immortalized mesencephalic progenitors (CSM14.1
RT   cells) into the neonatal parkinsonian rat caudate putamen.";
RL   J. Neurosci. Res. 85:778-786(2007).
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RX   PubMed=24592386; DOI=10.1155/2014/351821; PMCID=PMC3925624;
RA   Weiss B., Haas S.J.-P., Lessner G., Mikkat S., Kreutzer M.,
RA   Glocker M.O., Wree A., Schmitt O.;
RT   "The proteome of the differentiating mesencephalic progenitor cell
RT   line CSM14.1 in vitro.";
RL   BioMed Res. Int. 2014:351821.1-351821.13(2014).
//