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Cellosaurus UM-UC-2 (CVCL_8155)

[Text version]
Cell line name UM-UC-2
Synonyms UM-UC2; UMUC2; UC-2; University of Michigan-Urothelial Carcinoma-2
Accession CVCL_8155
Resource Identification Initiative To cite this cell line use: UM-UC-2 (RRID:CVCL_8155)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=19375735; PubMed=20143388). Originally thought to originate from a 61 year old male patient with a ureter transitional cell carcinoma.
Part of: BLA-40 bladder carcinoma cell line panel.
Part of: UBC-40 urothelial bladder cancer cell line index.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00281.
Population: Caucasian; Swedish.
Doubling time: 22 hours (PubMed=3761468).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=6471236; DOI=10.1016/S0022-5347(17)49883-1
Herbert Barton Grossman, Gary Wedemeyer, Li-Qin Ren;
UM-UC-1 and UM-UC-2: characterization of two new human transitional cell carcinoma lines.
J. Urol. 132:834-837(1984)

PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1
Herbert Barton Grossman, Gary Wedemeyer, Li-Qin Ren, Golder N. Wilson, Beth Cox;
Improved growth of human urothelial carcinoma cell cultures.
J. Urol. 136:953-959(1986)

PubMed=16469639; DOI=10.1016/S0022-5347(05)00323-X
Anita Lyn Sabichi, Afsaneh Keyhani, Noriyoshi Tanaka, Jorge Delacerda, I-Ling Lee, Chang-Ping Zou, Jian-Hua Zhou, William F. Benedict, Herbert Barton Grossman;
Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression.
J. Urol. 175:1133-1137(2006)

PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731
Hong-Seok Park, Weon Seo Park, Jolanta Bondaruk, Noriyoshi Tanaka, Hiroshi Katayama, Sangkyou Lee, Philippe E. Spiess, Jordan R. Steinberg, Zhi Wang, Ruth L. Katz, Colin Padraic Neal Dinney ...Show all 18 authors... , Keren J. Elias, Yair Lotan, Rizwan C. Naeem, Keith Baggerly, Subrata Sen, Herbert Barton Grossman, Bogdan Czerniak; Show fewer authors
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
J. Natl. Cancer Inst. 100:1401-1411(2008)

PubMed=19375735; DOI=10.1016/j.juro.2009.01.108; PMCID=PMC2680455
Edmund Chiong, Ali Dadbin, Loleta D. Harris, Anita Lyn Sabichi, Herbert Barton Grossman;
The use of short tandem repeat profiling to characterize human bladder cancer cell lines.
J. Urol. 181:2737-2748(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Yves Allory, Willemien Beukers, Ana Sagrera, Marta Flandez, Miriam Marques, Mirari Marquez, Kirstin A. van der Keur, Lars Dyrskjot, Irene Lurkin, Marcel Vermeij, Alfredo Carrato ...Show all 24 authors... , Josep Lloreta, Jose A. Lorente, Enrique Carrillo-de-Santa-Pau, Roy G. Masius, Manolis Kogevinas, Ewout Willem Steyerberg, Angela A.G. van Tilborg, Cheno Abas, Torben Falck Orntoft, Tahlita C.M. Zuiverloon, Nuria Malats, Ellen C. Zwarthoff, Francisco X. Real; Show fewer authors
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=26621286; DOI=10.1186/s12864-015-2227-4; PMCID=PMC4681452
Julie Earl, Daniel Rico, Enrique Carrillo-de-Santa-Pau, Benjamin Rodriguez-Santiago, Marinela Mendez-Pertuz, Herbert Auer, Gonzalo Gomez, Herbert Barton Grossman, David G. Pisano, Wolfgang A. Schulz, Luis A. Perez-Jurado ...Show all 16 authors... , Alfredo Carrato, Dan Theodorescu, Stephen Jacob Chanock, Alfonso Valencia, Francisco X. Real; Show fewer authors
Erratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:1019.1-1019.2(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8155
Anatomy/cell type resources BTO; BTO_0006290
Biological sample resources BioSample; SAMN03151953
Encyclopedic resources Wikidata; Q54990987
Gene expression databases GEO; GSM136237
Polymorphism and mutation databases Cosmic; 846277
Cosmic; 1302357
Cosmic; 2037968
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29