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Cellosaurus MTLn2 (CVCL_8133)

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Cell line name MTLn2
Accession CVCL_8133
Resource Identification Initiative To cite this cell line use: MTLn2 (RRID:CVCL_8133)
Comments Characteristics: Low metastatic potential. Established from a lung metastasis in a rat implanted with the DMBA-induced rat mammary adenocarcinoma 13762NF (PubMed=6950180).
Doubling time: 13.5 hours (PubMed=6950180).
Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Adenocarcinoma of the rat mammary gland (NCIt: C64011)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Fischer 344; RS=RS_0000215.
Hierarchy Children:
CVCL_8134 (MTLn2-Tf10)CVCL_8135 (MTLn2-Tf20)
Originate from same individual CVCL_E7H6 ! MTC
CVCL_8136 ! MTLn3
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=6950180; DOI=10.1093/jnci/68.3.507
Anthony Neri, Dan Welch, Takanori Kawaguchi, Garth L. Nicolson;
Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma.
J. Natl. Cancer Inst. 68:507-517(1982)

PubMed=9397155; DOI=10.1002/(SICI)1097-4652(199801)174:1<48::AID-JCP6>3.0.CO;2-G
Philip G. Cavanaugh, Garth L. Nicolson;
Selection of highly metastatic rat MTLn2 mammary adenocarcinoma cell variants using in vitro growth response to transferrin.
J. Cell. Physiol. 174:48-57(1998)

PubMed=21104427; DOI=10.1007/s10585-010-9362-8
Mustafa K. Dabbous, M. Margaret Jefferson, Lena Haney, Edwin L. Thomas;
Biomarkers of metastatic potential in cultured adenocarcinoma clones.
Clin. Exp. Metastasis 28:101-111(2011)

Cross-references
Encyclopedic resources Wikidata; Q54907008
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number10