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Cellosaurus HN-5 (CVCL_8128)

[Text version]
Cell line name HN-5
Synonyms HN5; LICR-LON-HN5; LICR (LON) HN5; LICR-HN5; LICR-HN-5; LICR HN-5
Accession CVCL_8128
Resource Identification Initiative To cite this cell line use: HN-5 (RRID:CVCL_8128)
Comments Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: 34 hours (PubMed=7195729).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Misspelling: HNS; Cosmic=1530740.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LI55 (LICR-HN5 R9.1)
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): PubMed=17254797; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,11 (PubMed=17254797)
11,13 (PubMed=21868764)
D3S135818
D5S81813
D7S82011
D8S117911,12
D13S31711
D16S53910,12 (PubMed=17254797)
11,13 (PubMed=21868764)
D18S5112,14
D21S1127,31
FGA24
TH019
TPOX8,11
vWA15,18,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=7195729; DOI=10.1038/bjc.1981.115; PMCID=PMC2010719
Dorothy M. Easty, Gerald C. Easty, Richard Lawrance Carter, Paul Monaghan, Leslie J. Butler;
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
Br. J. Cancer 43:772-785(1981)

PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6
Dorothy M. Easty, Gerald C. Easty, Antonio Baici, Richard Lawrance Carter, Stewart Anthony Cederholm-Williams, Heidi Felix, Barry Austin Gusterson, Gisela Haemmerli, Ingrid Helen Hauser-Urfer, Claus W. Heizmann, Marc M. Mareel ...Show all 13 authors... , B. Stehrenberger, Peter Strauli; Show fewer authors
Biological studies of ten human squamous carcinoma cell lines: an overview.
Eur. J. Cancer Clin. Oncol. 22:617-634(1986)

PubMed=2183872; DOI=10.1038/bjc.1990.80; PMCID=PMC1971288
Gill Rumsby, Richard Lawrance Carter, Barry Austin Gusterson;
Low incidence of ras oncogene activation in human squamous cell carcinomas.
Br. J. Cancer 61:365-368(1990)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I
Pornchai O-Charoenrat, Peter H. Rhys-Evans, Helmout Modjtahedi, William Court, Gary Box, Suzanne A. Eccles;
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.
Int. J. Cancer 86:307-317(2000)

PubMed=12124801; DOI=10.1002/ijc.10531
Pornchai O-Charoenrat, Peter H. Rhys-Evans, Suzanne A. Eccles;
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
Int. J. Cancer 100:527-533(2002)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26032726; DOI=10.1186/s13104-015-1197-6; PMCID=PMC4467624
Carolien Boeckx, Jolien Van den Bossche, Ines De Pauw, Marc Peeters, Filip Lardon, Marc Baay, An Wouters;
The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.
BMC Res. Notes 8:203.1-203.6(2015)

PubMed=26269754; PMCID=PMC4529614
Carolien Boeckx, Lina Blockx, Ken Op de Beeck, Ridha Limame, Guy Van Camp, Marc Peeters, Jan B. Vermorken, Pol Specenier, An Wouters, Marc Baay, Filip Lardon;
Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.
Am. J. Cancer Res. 5:1921-1938(2015)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections (Providers) NCBI_Iran; C196
Chemistry resources ChEMBL-Cells; CHEMBL3308481
ChEMBL-Targets; CHEMBL614828
PubChem_Cell_line; CVCL_8128
Encyclopedic resources Wikidata; Q54889993
Experimental variables resources EFO; EFO_0022405
Gene expression databases GEO; GSM1374540
GEO; GSM1374541
Polymorphism and mutation databases Cosmic; 686977
Cosmic; 706622
Cosmic; 916365
Cosmic; 1339911
Cosmic; 1530740
Cosmic; 2131847
Cosmic; 2439753
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29