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Cellosaurus HN-5 (CVCL_8128)

[Text version]

Cell line name HN-5
Synonyms HN5; LICR-LON-HN5; LICR (LON) HN5; LICR-HN5; LICR-HN-5; LICR HN-5
Accession CVCL_8128
Resource Identification Initiative To cite this cell line use: HN-5 (RRID:CVCL_8128)
Comments Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: 34 hours (PubMed=7195729).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Misspelling: HNS; In Cosmic 1530740.
Derived from sampling site: Oral cavity; tongue.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LI55 (LICR-HN5 R9.1 )
Sex of cell Male
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): PubMed=17254797; PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,11 (PubMed=17254797)
11,13 (PubMed=21868764)
D3S135818
D5S81813
D7S82011
D8S117911,12
D13S31711
D16S53910,12 (PubMed=17254797)
11,13 (PubMed=21868764)
D18S5112,14
D21S1127,31
FGA24
TH019
TPOX8,11
vWA15,18,19

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=7195729; DOI=10.1038/bjc.1981.115
Easty D.M., Easty G.C., Carter R.L., Monaghan P., Butler L.J.
Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck.
Br. J. Cancer 43:772-785(1981)

PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6
Easty D.M., Easty G.C., Baici A., Carter R.L., Cederholm-Williams S.A., Felix H., Gusterson B., Haemmerli G., Hauser-Urfer I.H., Heizmann C.W., Mareel M., Stehrenberger B., Strauli P.
Biological studies of ten human squamous carcinoma cell lines: an overview.
Eur. J. Cancer Clin. Oncol. 22:617-634(1986)

PubMed=2183872; DOI=10.1038/bjc.1990.80
Rumsby G., Carter R.L., Gusterson B.A.
Low incidence of ras oncogene activation in human squamous cell carcinomas.
Br. J. Cancer 61:365-368(1990)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I
O-Charoenrat P., Rhys-Evans P.H., Modjtahedi H., Court W., Box G., Eccles S.A.
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.
Int. J. Cancer 86:307-317(2000)

PubMed=12124801; DOI=10.1002/ijc.10531
O-Charoenrat P., Rhys-Evans P.H., Eccles S.A.
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
Int. J. Cancer 100:527-533(2002)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26032726; DOI=10.1186/s13104-015-1197-6
Boeckx C., Van den Bossche J., De Pauw I., Peeters M., Lardon F., Baay M., Wouters A.
The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.
BMC Res. Notes 8:203.1-203.6(2015)

PubMed=26269754
Boeckx C., Blockx L., de Beeck K.O., Limame R., Van Camp G., Peeters M., Vermorken J.B., Specenier P., Wouters A., Baay M., Lardon F.
Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.
Am. J. Cancer Res. 5:1921-1938(2015)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections NCBI_Iran; C196
Chemistry resources ChEMBL-Cells; CHEMBL3308481
ChEMBL-Targets; CHEMBL614828
Encyclopedic resources Wikidata; Q54889993
Gene expression databases GEO; GSM1374540
GEO; GSM1374541
Polymorphism and mutation databases Cosmic; 686977
Cosmic; 706622
Cosmic; 916365
Cosmic; 1339911
Cosmic; 1530740
Cosmic; 2131847
Cosmic; 2439753
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number24