ID   HN-5
AC   CVCL_8128
SY   HN5; LICR-LON-HN5; LICR (LON) HN5; LICR-HN5; LICR-HN-5; LICR HN-5
DR   EFO; EFO_0022405
DR   ChEMBL-Cells; CHEMBL3308481
DR   ChEMBL-Targets; CHEMBL614828
DR   Cosmic; 686977
DR   Cosmic; 706622
DR   Cosmic; 916365
DR   Cosmic; 1339911
DR   Cosmic; 1530740
DR   Cosmic; 2131847
DR   Cosmic; 2439753
DR   GEO; GSM1374540
DR   GEO; GSM1374541
DR   NCBI_Iran; C196
DR   PubChem_Cell_line; CVCL_8128
DR   Wikidata; Q54889993
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=2183872;
RX   PubMed=2427339;
RX   PubMed=7195729;
RX   PubMed=10760816;
RX   PubMed=12124801;
RX   PubMed=17254797;
RX   PubMed=21868764;
RX   PubMed=26032726;
RX   PubMed=26269754;
RX   PubMed=26754630;
RX   PubMed=28196595;
RX   PubMed=29156801;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Doubling time: 34 hours (PubMed=7195729).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Misspelling: HNS; Cosmic=1530740.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): PubMed=17254797; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 10,11 (PubMed=17254797)
ST   CSF1PO: 11,13 (PubMed=21868764)
ST   D13S317: 11
ST   D16S539: 10,12 (PubMed=17254797)
ST   D16S539: 11,13 (PubMed=21868764)
ST   D18S51: 12,14
ST   D21S11: 27,31
ST   D3S1358: 18
ST   D5S818: 13
ST   D7S820: 11
ST   D8S1179: 11,12
ST   FGA: 24
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 15,18,19
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   73Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
CH   CVCL_LI55 ! LICR-HN5 R9.1
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=12124801; DOI=10.1002/ijc.10531;
RA   O-Charoenrat, Pornchai
RA   Rhys-Evans, Peter H.
RA   Eccles, Suzanne A.
RT   "A synthetic matrix metalloproteinase inhibitor prevents squamous
RT   carcinoma cell proliferation by interfering with epidermal growth
RT   factor receptor autocrine loops.";
RL   Int. J. Cancer 100:527-533(2002).
//
RX   PubMed=2427339; DOI=10.1016/0277-5379(86)90158-6;
RA   Easty, Dorothy M.
RA   Easty, Gerald C.
RA   Baici, Antonio
RA   Carter, Richard Lawrance
RA   Cederholm-Williams, Stewart Anthony
RA   Felix, Heidi
RA   Gusterson, Barry Austin
RA   Haemmerli, Gisela
RA   Hauser-Urfer, Ingrid Helen
RA   Heizmann, Claus W.
RA   Mareel, Marc M.
RA   Stehrenberger, B.
RA   Strauli, Peter
RT   "Biological studies of ten human squamous carcinoma cell lines: an
RT   overview.";
RL   Eur. J. Cancer Clin. Oncol. 22:617-634(1986).
//
RX   PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001;
RA   Azari, Shahram
RA   Ahmadi, Nahid
RA   Jeddi-Tehrani, Mahmood
RA   Shokri, Fazel
RT   "Profiling and authentication of human cell lines using short tandem
RT   repeat (STR) loci: report from the National Cell Bank of Iran.";
RL   Biologicals 35:195-202(2007).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=10760816; DOI=10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I;
RA   O-Charoenrat, Pornchai
RA   Rhys-Evans, Peter H.
RA   Modjtahedi, Helmout
RA   Court, William
RA   Box, Gary
RA   Eccles, Suzanne A.
RT   "Overexpression of epidermal growth factor receptor in human head and
RT   neck squamous carcinoma cell lines correlates with matrix
RT   metalloproteinase-9 expression and in vitro invasion.";
RL   Int. J. Cancer 86:307-317(2000).
//
RX   PubMed=26032726; DOI=10.1186/s13104-015-1197-6; PMCID=PMC4467624;
RA   Boeckx, Carolien
RA   Van den Bossche, Jolien
RA   De Pauw, Ines
RA   Peeters, Marc
RA   Lardon, Filip
RA   Baay, Marc
RA   Wouters, An
RT   "The hypoxic tumor microenvironment and drug resistance against EGFR
RT   inhibitors: preclinical study in cetuximab-sensitive head and neck
RT   squamous cell carcinoma cell lines.";
RL   BMC Res. Notes 8:203.1-203.6(2015).
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey, Thomas E.
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=26269754; PMCID=PMC4529614;
RA   Boeckx, Carolien
RA   Blockx, Lina
RA   Op de Beeck, Ken
RA   Limame, Ridha
RA   Van Camp, Guy
RA   Peeters, Marc
RA   Vermorken, Jan B.
RA   Specenier, Pol
RA   Wouters, An
RA   Baay, Marc
RA   Lardon, Filip
RT   "Establishment and characterization of cetuximab resistant head and
RT   neck squamous cell carcinoma cell lines: focus on the contribution of
RT   the AP-1 transcription factor.";
RL   Am. J. Cancer Res. 5:1921-1938(2015).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao, Mei
RA   Sano, Daisuke
RA   Pickering, Curtis R.
RA   Jasser, Samar A.
RA   Henderson, Ying C.
RA   Clayman, Gary L.
RA   Sturgis, Erich M.
RA   Ow, Thomas J.
RA   Lotan, Reuben
RA   Carey, Thomas E.
RA   Sacks, Peter G.
RA   Grandis, Jennifer Rubin
RA   Sidransky, David
RA   Heldin, Nils-Erik
RA   Myers, Jeffrey N.
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=7195729; DOI=10.1038/bjc.1981.115; PMCID=PMC2010719;
RA   Easty, Dorothy M.
RA   Easty, Gerald C.
RA   Carter, Richard Lawrance
RA   Monaghan, Paul
RA   Butler, Leslie J.
RT   "Ten human carcinoma cell lines derived from squamous carcinomas of
RT   the head and neck.";
RL   Br. J. Cancer 43:772-785(1981).
//
RX   PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939;
RA   Hyakusoku, Hiroshi
RA   Sano, Daisuke
RA   Takahashi, Hideaki
RA   Hatano, Takashi
RA   Isono, Yasuhiro
RA   Shimada, Shoko
RA   Ito, Yusuke
RA   Myers, Jeffrey N.
RA   Oridate, Nobuhiko
RT   "JunB promotes cell invasion, migration and distant metastasis of head
RT   and neck squamous cell carcinoma.";
RL   J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
//
RX   PubMed=2183872; DOI=10.1038/bjc.1990.80; PMCID=PMC1971288;
RA   Rumsby, Gill
RA   Carter, Richard Lawrance
RA   Gusterson, Barry Austin
RT   "Low incidence of ras oncogene activation in human squamous cell
RT   carcinomas.";
RL   Br. J. Cancer 61:365-368(1990).
//