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Cellosaurus SK-GT-5 (CVCL_8114)

[Text version]
Cell line name SK-GT-5
Synonyms SKGT5
Accession CVCL_8114
Resource Identification Initiative To cite this cell line use: SK-GT-5 (RRID:CVCL_8114)
Comments Problematic cell line: Contaminated. Shown to be a SK-GT-2 derivative (PubMed=20075370). Originally thought to originate from a 67 year old male patient with an esophageal adenocarcinoma.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00368.
Population: Hispanic.
Doubling time: 41 hours (PubMed=8334620).
Caution: TP53 mutation indicated incorrectly as being at p.Asp281Glu (c.843C>G) in PubMed=7665247.
Derived from site: In situ; Stomach, fundus; UBERON=UBERON_0001160.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Gastric fundus carcinoma (NCIt: C8398)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2194 (SK-GT-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): PubMed=20075370

Penta D9
Penta E15,17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=8334620; DOI=10.1002/1097-0142(19930801)72:3<649::AID-CNCR2820720305>3.0.CO;2-L
Altorki N.K., Schwartz G.K., Blundell M.L., Davis B.M., Kelsen D.P., Albino A.P.
Characterization of cell lines established from human gastric-esophageal adenocarcinomas. Biologic phenotype and invasion potential.
Cancer 72:649-657(1993)

PubMed=7665247; DOI=10.1002/ijc.2910640109
Nabeya Y., Loganzo F. Jr., Maslak P., Lai L., de Oliveira A.R., Schwartz G.K., Blundell M.L., Altorki N.K., Kelsen D.P., Albino A.P.
The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents.
Int. J. Cancer 64:37-46(1995)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

Cell line databases/resources cancercelllines; CVCL_8114
Biological sample resources BioSample; SAMN03151916
Encyclopedic resources Wikidata; Q54953663
Polymorphism and mutation databases IARC_TP53; 4080
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26