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Cellosaurus SK-GT-2 (CVCL_2194)

[Text version]

Cell line name SK-GT-2
Synonyms SKGT2
Accession CVCL_2194
Resource Identification Initiative To cite this cell line use: SK-GT-2 (RRID:CVCL_2194)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Hispanic.
Doubling time: 44 hours (PubMed=8334620); ~48 hours (DSMZ); ~44 hours (ECACC).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Stomach; fundus.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (PubMed=7665247; Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African20.34
Native American14.81
East Asian, North2.09
East Asian, South0
South Asian0
European, North30.94
European, South31.83
Disease Gastric fundus carcinoma (NCIt: C8398)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8114 (SK-GT-5 )
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ; ECACC

Markers:
AmelogeninX
CSF1PO10
D2S133816,19
D3S135815
D5S81810
D7S8209,10
D8S117915
D13S31712,13
D16S53911,12
D18S5114,15
D19S43312
D21S1132 (DSMZ)
32.2 (DepMap)
FGA26
Penta D9
Penta E15,17
TH018,9
TPOX9,12
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=8334620; DOI=10.1002/1097-0142(19930801)72:3<649::AID-CNCR2820720305>3.0.CO;2-L
Altorki N., Schwartz G.K., Blundell M., Davis B.M., Kelsen D.P., Albino A.P.
Characterization of cell lines established from human gastric-esophageal adenocarcinomas. Biologic phenotype and invasion potential.
Cancer 72:649-657(1993)

PubMed=7665247; DOI=10.1002/ijc.2910640109
Nabeya Y., Loganzo F. Jr., Maslak P., Lai L., de Oliveira A.R., Schwartz G.K., Blundell M.L., Altorki N.K., Kelsen D.P., Albino A.P.
The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents.
Int. J. Cancer 64:37-46(1995)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections DSMZ; ACC-702
ECACC; 11012008
Cell line databases/resources Cell_Model_Passport; SIDM00393
Cosmic-CLP; 1503364
DepMap; ACH-001653
DSMZCellDive; ACC-702
Biological sample resources BioSample; SAMN03473450
Chemistry resources GDSC; 1503364
PharmacoDB; SKGT2_1388_2019
Encyclopedic resources Wikidata; Q54953659
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670430
Polymorphism and mutation databases IARC_TP53; 4078
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number24