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Cellosaurus SEG-1 (CVCL_8113)

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Cell line name SEG-1
Synonyms Seg-1; SEG1; Seg1
Accession CVCL_8113
Resource Identification Initiative To cite this cell line use: SEG-1 (RRID:CVCL_8113)
Comments Problematic cell line: Contaminated. Shown to be a NCI-H460 derivative (PubMed=20075370). Originally thought to originate from an esophageal Barrett adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00366.
Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=20075370

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,18
D5S8189,10
D7S8209,12
D8S117912
D13S31713
D16S5399
D18S5113,15
D21S1130
FGA21,23
Penta D11,13
Penta E5
TH019.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9407969
Steven J. Hughes, Yoshihiro Nambu, Oliver Stephen Soldes, Daniel Hamstra, Alnawaz Rehemtulla, Mark D. Iannettoni, Mark B. Orringer, David G. Beer;
Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.
Cancer Res. 57:5571-5578(1997)

PubMed=10078940; DOI=10.1002/(SICI)1098-2744(199902)24:2<128::AID-MC7>3.0.CO;2-F
Keith R. Compton, Mark B. Orringer, David G. Beer;
Induction of glutathione s-transferase-pi in Barrett's metaplasia and Barrett's adenocarcinoma cell lines.
Mol. Carcinog. 24:128-136(1999)

PubMed=16364037; DOI=10.1111/j.1442-2050.2006.00530.x
M. Su, Suet-Feung Chin, X.-Y. Li, Paul A.W. Edwards, Carlos Caldas, Rebecca Clare Fitzgerald;
Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.
Dis. Esophagus 19:10-14(2006)

PubMed=20075370; DOI=10.1093/jnci/djp499; PMCID=PMC2902814
Jurjen J. Boonstra, Ronald van Marion, David G. Beer, Lin Lin, Patricia Chaves, Catarina Ribeiro, A. Dias Pereira, Lucia Roque, S. Jane Darnton, Nasser Khaled Altorki, David S. Schrump ...Show all 19 authors... , David S. Klimstra, Laura H. Tang, James Richard Eshleman, Hector Alvarez, Yutaka Shimada, Herman van Dekken, Hugo W. Tilanus, Winand N.M. Dinjens; Show fewer authors
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Jurjen J. Boonstra, Hugo W. Tilanus, Winand N.M. Dinjens;
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8113
Anatomy/cell type resources BTO; BTO_0003430
Biological sample resources BioSample; SAMN03151859
Encyclopedic resources Wikidata; Q54952784
Polymorphism and mutation databases IARC_TP53; 21627
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29