ID   SEG-1
AC   CVCL_8113
SY   Seg-1; SEG1; Seg1
DR   BTO; BTO:0003430
DR   BioSample; SAMN03151859
DR   cancercelllines; CVCL_8113
DR   IARC_TP53; 21627
DR   Wikidata; Q54952784
RX   PubMed=9407969;
RX   PubMed=10078940;
RX   PubMed=16364037;
RX   PubMed=20075370;
RX   PubMed=23795680;
CC   Problematic cell line: Contaminated. Shown to be a NCI-H460 derivative (PubMed=20075370). Originally thought to originate from an esophageal Barrett adenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00366.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=20075370
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 13
ST   D16S539: 9
ST   D18S51: 13,15
ST   D21S11: 30
ST   D3S1358: 15,18
ST   D5S818: 9,10
ST   D7S820: 9,12
ST   D8S1179: 12
ST   FGA: 21,23
ST   Penta D: 11,13
ST   Penta E: 5
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 27
RX   PubMed=9407969;
RA   Hughes S.J., Nambu Y., Soldes O.S., Hamstra D., Rehemtulla A.,
RA   Iannettoni M.D., Orringer M.B., Beer D.G.;
RT   "Fas/APO-1 (CD95) is not translocated to the cell membrane in
RT   esophageal adenocarcinoma.";
RL   Cancer Res. 57:5571-5578(1997).
RX   PubMed=10078940; DOI=10.1002/(SICI)1098-2744(199902)24:2<128::AID-MC7>3.0.CO;2-F;
RA   Compton K.R., Orringer M.B., Beer D.G.;
RT   "Induction of glutathione s-transferase-pi in Barrett's metaplasia and
RT   Barrett's adenocarcinoma cell lines.";
RL   Mol. Carcinog. 24:128-136(1999).
RX   PubMed=16364037; DOI=10.1111/j.1442-2050.2006.00530.x;
RA   Su M., Chin S.-F., Li X.-Y., Edwards P.A.W., Caldas C.,
RA   Fitzgerald R.C.;
RT   "Comparative genomic hybridization of esophageal adenocarcinoma and
RT   squamous cell carcinoma cell lines.";
RL   Dis. Esophagus 19:10-14(2006).
RX   PubMed=20075370; DOI=10.1093/jnci/djp499;
RA   Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P.,
RA   Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K.,
RA   Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H.,
RA   Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.;
RT   "Verification and unmasking of widely used human esophageal
RT   adenocarcinoma cell lines.";
RL   J. Natl. Cancer Inst. 102:271-274(2010).
RX   PubMed=23795680; DOI=10.1111/dote.12095;
RA   Boonstra J.J., Tilanus H.W., Dinjens W.N.M.;
RT   "Translational research on esophageal adenocarcinoma: from cell line
RT   to clinic.";
RL   Dis. Esophagus 28:90-96(2015).