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Cellosaurus JH-EsoAd1 (CVCL_8098)

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Cell line name JH-EsoAd1
Synonyms JHEsoAD1; JHesoAD1; JHESOAD1; EsoAd1; Johns Hopkins-Esophageal Adenocarcinoma 1
Accession CVCL_8098
Resource Identification Initiative To cite this cell line use: JH-EsoAd1 (RRID:CVCL_8098)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 20 hours (PubMed=18787394); 29 hours (PubMed=25984343).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; shRNA library screening.
Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.64
Native American0
East Asian, North1.94
East Asian, South0
South Asian0
European, North58.42
European, South38.99
Disease Barrett adenocarcinoma (NCIt: C7027)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=18787394; PubMed=20075370

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81811
D7S82010,12
D8S117910
D13S31711
D16S53910,12
D18S5112
D21S1130
FGA24
Penta D14
Penta E11
TH016,7
TPOX8,9
vWA18,19 (PubMed=20075370)
19 (PubMed=18787394)

Run an STR similarity search on this cell line
Publications

PubMed=18787394; DOI=10.4161/cbt.7.11.6723; PMCID=PMC3596869
Hector Alvarez, Jan-Bart M. Koorstra, Seung-Mo Hong, Jurjen J. Boonstra, Winand N.M. Dinjens, Arlene Ann Forastiere, Tsung-Teh Wu, Elizabeth Anne Montgomery, James Richard Eshleman, Anirban Maitra;
Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line.
Cancer Biol. Ther. 7:1753-1755(2008)

PubMed=18981730; DOI=10.4161/cbt.7.11.7200
Douglas B. Stairs, Shinya Ohashi, Hiroshi Nakagawa;
Cellular biometrics in the postgenomics era.
Cancer Biol. Ther. 7:1756-1757(2008)

PubMed=20075370; DOI=10.1093/jnci/djp499; PMCID=PMC2902814
Jurjen J. Boonstra, Ronald van Marion, David G. Beer, Lin Lin, Patricia Chaves, Catarina Ribeiro, A. Dias Pereira, Lucia Roque, S. Jane Darnton, Nasser Khaled Altorki, David S. Schrump ...Show all 19 authors... , David S. Klimstra, Laura H. Tang, James Richard Eshleman, Hector Alvarez, Yutaka Shimada, Herman van Dekken, Hugo W. Tilanus, Winand N.M. Dinjens; Show fewer authors
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=23795680; DOI=10.1111/dote.12095
Jurjen J. Boonstra, Hugo W. Tilanus, Winand N.M. Dinjens;
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27594985; DOI=10.12688/f1000research.7033.1; PMCID=PMC4991527
Gianmarco Contino, Matthew D. Eldridge, Maria Secrier, Lawrence Bower, Rachael Fels Elliott, Jamie Weaver, Andy G. Lynch, Paul A.W. Edwards, Rebecca Clare Fitzgerald;
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336.1-1336.12(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8098
Cell_Model_Passport; SIDM01731
DepMap; ACH-000216
Biological sample resources BioSample; SAMN10988422
Chemistry resources PharmacoDB; JHEsoAd1_679_2019
Encyclopedic resources Wikidata; Q54898624
Polymorphism and mutation databases Cosmic; 1599340
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24