ID   JH-EsoAd1
AC   CVCL_8098
SY   JHEsoAD1; JHesoAD1; JHESOAD1; EsoAd1; Johns Hopkins-Esophageal Adenocarcinoma 1
DR   BioSample; SAMN10988422
DR   cancercelllines; CVCL_8098
DR   Cell_Model_Passport; SIDM01731
DR   Cosmic; 1599340
DR   DepMap; ACH-000216
DR   PharmacoDB; JHEsoAd1_679_2019
DR   Wikidata; Q54898624
RX   PubMed=18787394;
RX   PubMed=18981730;
RX   PubMed=20075370;
RX   PubMed=23795680;
RX   PubMed=25984343;
RX   PubMed=27594985;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 20 hours (PubMed=18787394); 29 hours (PubMed=25984343).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Homozygous (PubMed=18787394; PubMed=20075370; DepMap=ACH-000216).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Phenotyping; shRNA library screening.
CC   Genome ancestry: African=0.64%; Native American=0%; East Asian, North=1.94%; East Asian, South=0%; South Asian=0%; European, North=58.42%; European, South=38.99% (PubMed=30894373).
CC   Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
ST   Source(s): PubMed=18787394; PubMed=20075370
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 10,12
ST   D18S51: 12
ST   D21S11: 30
ST   D3S1358: 16
ST   D5S818: 11
ST   D7S820: 10,12
ST   D8S1179: 10
ST   FGA: 24
ST   Penta D: 14
ST   Penta E: 11
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 18,19 (PubMed=20075370)
ST   vWA: 19 (PubMed=18787394)
DI   NCIt; C7027; Barrett adenocarcinoma
DI   ORDO; Orphanet_99976; Adenocarcinoma of the esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=18787394; DOI=10.4161/cbt.7.11.6723; PMCID=PMC3596869;
RA   Alvarez H., Koorstra J.-B.M., Hong S.-M., Boonstra J.J., Dinjens W.N.M.,
RA   Forastiere A.A., Wu T.-T., Montgomery E.A., Eshleman J.R., Maitra A.;
RT   "Establishment and characterization of a bona fide Barrett
RT   esophagus-associated adenocarcinoma cell line.";
RL   Cancer Biol. Ther. 7:1753-1755(2008).
//
RX   PubMed=18981730; DOI=10.4161/cbt.7.11.7200;
RA   Stairs D.B., Ohashi S., Nakagawa H.;
RT   "Cellular biometrics in the postgenomics era.";
RL   Cancer Biol. Ther. 7:1756-1757(2008).
//
RX   PubMed=20075370; DOI=10.1093/jnci/djp499; PMCID=PMC2902814;
RA   Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P.,
RA   Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K.,
RA   Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H.,
RA   Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.;
RT   "Verification and unmasking of widely used human esophageal
RT   adenocarcinoma cell lines.";
RL   J. Natl. Cancer Inst. 102:271-274(2010).
//
RX   PubMed=23795680; DOI=10.1111/dote.12095;
RA   Boonstra J.J., Tilanus H.W., Dinjens W.N.M.;
RT   "Translational research on esophageal adenocarcinoma: from cell line
RT   to clinic.";
RL   Dis. Esophagus 28:90-96(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=27594985; DOI=10.12688/f1000research.7033.1; PMCID=PMC4991527;
RA   Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J.,
RA   Lynch A.G., Edwards P.A.W., Fitzgerald R.C.;
RT   "Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.";
RL   F1000Research 5:1336.1-1336.12(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//