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Cellosaurus TF-1 D2 (CVCL_8059)

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Cell line name TF-1 D2
Synonyms D2
Accession CVCL_8059
Resource Identification Initiative To cite this cell line use: TF-1 D2 (RRID:CVCL_8059)
Comments Population: Japanese.
Characteristics: Growth factor independent clone of TF-1.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:15868; ABHD12 + HGNC; HGNC:1537; CBFA2T3; Name(s)=CBFA2T3-ABHD12 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Pro (c.182A>C); ClinVar=VCV000280409; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Thrfs*94 (c.752delT); ClinVar=VCV001759367; Zygosity=Unspecified (from parent cell line).
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0559 (TF-1)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=9038380; DOI=10.1038/sj.onc.1200884
Jhy-Rong Chao, Chyi-Shyan Chen, Ting-Fang Wang, Li-Hui Tseng, Jaw-Ji Tsai, Min-Liang Kuo, Jeffrey J.-Y. Yen, Hsing-Fang Yang Yen;
Characterization of factor-independent variants derived from TF-1 hematopoietic progenitor cells: the role of the Raf/MAP kinase pathway in the anti-apoptotic effect of GM-CSF.
Oncogene 14:721-728(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8059
Encyclopedic resources Wikidata; Q54817182
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number20