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Cellosaurus KMCH-1 (CVCL_7970)

[Text version]
Cell line name KMCH-1
Synonyms KMCH1; KMCH
Accession CVCL_7970
Resource Identification Initiative To cite this cell line use: KMCH-1 (RRID:CVCL_7970)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~39 hours (PubMed=3032760).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Tyr346Cys (c.1037A>G); ClinVar=VCV000480380; Zygosity=Unspecified (DepMap=ACH-001853).
HLA typing Source: PubMed=9178645
Class I
HLA-AA*11:01,31:01
HLA-BB*51:01
HLA-CC*14:02
Class II
HLA-DRDRB1*08:02
Disease Combined hepatocellular carcinoma and cholangiocarcinoma (NCIt: C3828)
Combined hepatocellular carcinoma and cholangiocarcinoma (ORDO: Orphanet_529852)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001853

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S81812,13
D7S82010,12
D8S117910,14
D13S31711
D16S53910
D18S5113
D21S1129
FGA22
Penta D9
Penta E11,18
TH019.3
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3032760; DOI=10.1002/hep.1840070322
Tatsuo Murakami, Hirohisa Yano, Masafumi Maruiwa, Shigetaka Sugihara, Masamichi Kojiro;
Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice.
Hepatology 7:551-556(1987)

PubMed=7537711; DOI=10.1002/hep.1840210510
Makoto Haramaki, Hirohisa Yano, Kazunori Fukuda, Seiya Momosaki, Sachiko Ogasawara, Masamichi Kojiro;
Expression of CD44 in human hepatocellular carcinoma cell lines.
Hepatology 21:1276-1284(1995)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Masanobu Nakao, Michio Sata, Hideki Saitsu, Shigeru Yutani, Mayumi Kawamoto, Masamichi Kojiro, Kyogo Itoh;
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=10347112; DOI=10.1002/hep.510290624
Hirohisa Yano, Akihiro Iemura, Makoto Haramaki, Sachiko Ogasawara, Akiko Takayama, Jun Akiba, Masamichi Kojiro;
Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines.
Hepatology 29:1708-1717(1999)

CLPUB00275
Sebastian Zach, Emrullah Birgin, Felix Ruckert;
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451
Dominique Scherer, Marcela Davila-Lopez, Benjamin Goeppert, Sanna Abrahamsson, Rosa Gonzalez Silos, Igor Nova, Katherine Marcelain, Juan Carlos Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge ...Show all 13 authors... , Stephanie Roessler, Justo Lorenzo-Bermejo; Show fewer authors
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7970
Cell_Model_Passport; SIDM01800
DepMap; ACH-001853
Anatomy/cell type resources BTO; BTO_0003310
Encyclopedic resources Wikidata; Q54900108
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24