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Cellosaurus 253J-BV (CVCL_7937)

[Text version]
Cell line name 253J-BV
Synonyms 253JB-V; 253J B-V; 253JBV; 253J-Bladder-V
Accession CVCL_7937
Resource Identification Initiative To cite this cell line use: 253J-BV (RRID:CVCL_7937)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Characteristics: Metastatic phenotype. Obtained after 5 serial passages of the parent cell line in the bladder of nude mice.
Doubling time: 49 +- 5 hours (PubMed=7658585).
Microsatellite instability: Stable (MSS) (PubMed=31068700).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Retroperitoneal lymph node; UBERON=UBERON_0035371.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,03:01
HLA-BB*08:01,51:01
HLA-CC*07:06,12:03
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7935 (253J)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): KCLB=80002

Markers:
AmelogeninX
CSF1PO10,12
D3S135815
D5S81810,12
D7S8209
D13S3179
FGA23,24
TH016,9.3
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=7658585; DOI=10.1016/S0022-5347(01)66923-4
Colin Padraic Neal Dinney, Randi Fishbeck, Rakesh K. Singh, Beryl Eve, Sen Pathak, Nicolas Brown, Bei Xie, Dominic Fan, Corazon D. Bucana, Isaiah Joshua Fidler, Jerald J. Killion;
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice.
J. Urol. 154:1532-1538(1995)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) KCLB; 80002
Cell line databases/resources cancercelllines; CVCL_7937
Cell_Model_Passport; SIDM01624
DepMap; ACH-000026
Anatomy/cell type resources BTO; BTO_0004894
Biological sample resources BioSample; SAMN10987963
Chemistry resources PharmacoDB; 253JBV_15_2019
Encyclopedic resources Wikidata; Q54583655
Experimental variables resources EFO; EFO_0022648
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM136239
Polymorphism and mutation databases Cosmic; 846282
Cosmic; 1082645
Cosmic; 1938695
IARC_TP53; 30015
LiGeA; CCLE_144
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27