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Cellosaurus GM00847 (CVCL_7908)

[Text version]
Cell line name GM00847
Synonyms LN-SV; LNSV; GM-847; GM 847; GM847
Accession CVCL_7908
Resource Identification Initiative To cite this cell line use: GM00847 (RRID:CVCL_7908)
Comments Population: African American.
Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Lesch-Nyhan syndrome (NCIt: C61255)
Lesch-Nyhan syndrome (ORDO: Orphanet_510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F127 (GM02063)
CVCL_7252 (CL 21)CVCL_D343 (GM15836)CVCL_7947 (GM847/ATRkd)
Sex of cell Male
Age at sampling 5Y6M
Category Transformed cell line

PubMed=174085; DOI=10.1073/pnas.72.12.4971
Stiles C.D., Desmond W. Jr., Sato G.H., Saier M.H. Jr.
Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice.
Proc. Natl. Acad. Sci. U.S.A. 72:4971-4975(1975)

Stiles C.D., Desmond W. Jr., Chuman L.M., Sato G.H., Saier M.H. Jr.
Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse.
Cancer Res. 36:1353-1360(1976)

Coriell L.L., Greene A.E.
The human genetic mutant cell repository: list of genetic variants, chromosomal aberrations and normal cell cultures submitted to the repository. 4th edition. October 1977.
(In) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda (1977)

PubMed=191830; DOI=10.1073/pnas.74.3.1142
Koprowski H., Croce C.M.
Tumorigenicity of simian virus 40-transformed human cells and mouse-human hybrids in nude mice.
Proc. Natl. Acad. Sci. U.S.A. 74:1142-1146(1977)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042
Pereira-Smith O.M., Smith J.R.
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

PubMed=11359895; DOI=10.1128/MCB.21.12.3862-3875.2001
Perrem K., Colgin L.M., Neumann A.A., Yeager T.R., Reddel R.R.
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells.
Mol. Cell. Biol. 21:3862-3875(2001)

PubMed=12361951; DOI=10.1074/jbc.M207937200
Donahue S.L., Campbell C.
A DNA double strand break repair defect in Fanconi anemia fibroblasts.
J. Biol. Chem. 277:46243-46247(2002)

Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=26001292; DOI=10.18632/oncotarget.3846
Napier C.E., Huschtscha L.I., Harvey A., Bower K., Noble J.R., Hendrickson E.A., Reddel R.R.
ATRX represses alternative lengthening of telomeres.
Oncotarget 6:16543-16558(2015)

Cell line collections (Providers) Coriell; GM00847
Cell line databases/resources CLO; CLO_0029655
Encyclopedic resources Wikidata; Q54836472
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number23