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Cellosaurus GM00847 (CVCL_7908)

[Text version]
Cell line name GM00847
Synonyms LN-SV; LNSV; GM-847; GM 847; GM847
Accession CVCL_7908
Resource Identification Initiative To cite this cell line use: GM00847 (RRID:CVCL_7908)
Comments Population: African American.
Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Lesch-Nyhan syndrome (NCIt: C61255)
Lesch-Nyhan syndrome (ORDO: Orphanet_510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F127 (GM02063)
Children:
CVCL_7252 (CL 21)CVCL_D343 (GM15836)CVCL_7947 (GM847/ATRkd)
CVCL_C1HE (GM847/hTERT-3)CVCL_C1HF (GM847/hTERT-6)
Sex of cell Male
Age at sampling 5Y6M
Category Transformed cell line
Publications

PubMed=174085; DOI=10.1073/pnas.72.12.4971; PMCID=PMC388856
Charles Dean Stiles, Walter Desmond Jr., Gordon Hisashi Sato, Milton H. Saier Jr.;
Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice.
Proc. Natl. Acad. Sci. U.S.A. 72:4971-4975(1975)

PubMed=1260760
Charles Dean Stiles, Walter Desmond Jr., Lorraine M. Chuman, Gordon Hisashi Sato, Milton H. Saier Jr.;
Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse.
Cancer Res. 36:1353-1360(1976)

DOI=10.5962/bhl.title.4090
Lewis Lemon Coriell, Arthur E. Greene;
The human genetic mutant cell repository: list of genetic variants, chromosomal aberrations and normal cell cultures submitted to the repository. 4th edition. October 1977.
(In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda; USA (1977)

PubMed=191830; DOI=10.1073/pnas.74.3.1142; PMCID=PMC430625
Hilary Koprowski, Carlo Maria Croce;
Tumorigenicity of simian virus 40-transformed human cells and mouse-human hybrids in nude mice.
Proc. Natl. Acad. Sci. U.S.A. 74:1142-1146(1977)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042; PMCID=PMC281901
Olivia M. Pereira-Smith, James R. Smith;
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

CLPUB00447
Richard A. Mulivor, Sharon F. Suchy;
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Tracy M. Bryan, Lidija Marusic, Silvia Bacchetti, Masayoshi Namba, Roger Robert Reddel;
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

PubMed=11359895; DOI=10.1128/mcb.21.12.3862-3875.2001; PMCID=PMC87050
Kilian Perrem, Lorel M. Colgin, Axel A. Neumann, Thomas R. Yeager, Roger Robert Reddel;
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells.
Mol. Cell. Biol. 21:3862-3875(2001)

PubMed=12361951; DOI=10.1074/jbc.M207937200
Sarah L. Donahue, Colin Campbell;
A DNA double strand break repair defect in Fanconi anemia fibroblasts.
J. Biol. Chem. 277:46243-46247(2002)

CLPUB00712
Jeremy David Henson;
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=26001292; DOI=10.18632/oncotarget.3846; PMCID=PMC4599288
Christine E. Napier, Lily I. Huschtscha, Adam Harvey, Kylie Bower, Jane R. Noble, Eric A. Hendrickson, Roger Robert Reddel;
ATRX represses alternative lengthening of telomeres.
Oncotarget 6:16543-16558(2015)

Cross-references
Cell line collections (Providers) Coriell; GM00847
Cell line databases/resources CLO; CLO_0029655
Encyclopedic resources Wikidata; Q54836472
Experimental variables resources EFO; EFO_0022519
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number24