Cellosaurus cell line UT-SCC-54B (CVCL

Cellosaurus UT-SCC-54B (CVCL_7864)

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Cell line name

UT-SCC-54B

Synonyms

University of Turku-Squamous Cell Carcinoma-54B

Accession

CVCL_7864

Resource Identification Initiative

To cite this cell line use: UT-SCC-54B (RRID:CVCL_7864)

Comments

Omics: Genomics; Whole exome sequencing.
Caution: UT-SCC-54A, UT-SCC-54B and UT-SCC-54C are supposed to originate from the same patient but the STR profile of UT-SCC-54C is totally different from that of the two other cell lines.
Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Unspecified (PubMed=15287027).

Disease

Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_7863 ! UT-SCC-54A
CVCL_A7DW ! UT-SCC-54C

Sex of cell

Female

Age at sampling

58Y

Category

Cancer cell line

STR profile

Source(s): PubMed=30135316

Markers:

Amelogenin	X
CSF1PO	10
D2S1338	20,24
D3S1358	17
D5S818	11
D7S820	12
D8S1179	10,14
D13S317	12
D16S539	11,12
D18S51	16
D19S433	14
D21S11	31,32.2
FGA	21,26
TH01	9.3
TPOX	8,9
vWA	14,18

Publications

PubMed=15287027; DOI=10.1002/gcc.20066
Satoru Takebayashi, Arthur Hickson, Tetsuya Ogawa, Kwang-Yoon Jung, Hiroyuki Mineta, Yo Ueda, Reidar Grenman, Susan G. Fisher, Thomas E. Carey;
Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer.
Genes Chromosomes Cancer 41:145-154(2004)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=30135316; DOI=10.1172/jci.insight.122204; PMCID=PMC6141174
Stephen M.F. Jamieson, Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John Joseph Nemunaitis, Dennis Kee, Avik Shome ...Show all 35 authors... , Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R.H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar Grenman, Laura Caporiccio, Trevor David McKee, Mark Zaidi, Sehrish Butt, Andrew M.J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan Klaus Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin Gregor Print, William R. Wilson, Michael A. Curran, Francis W. Hunter; Show fewer authors
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
JCI Insight 3:e122204.1-e122204.19(2018)

DOI=10.1158/1538-7445.AM2020-507
Maria K. Kondratyev, Aleksandra Pesic, Anna Dvorkin-Sheva, Troy Ketela, Jason Moffat, Marianne Koritzinsky, Bradly G. Wouters;
Repurposing of FDA approved drugs for treatment of metastatic HNSCC.
Cancer Res. 80 Suppl. 16:507-507(2020)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_7864

Encyclopedic resources

Wikidata; Q54992154

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number