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Cellosaurus UT-SCC-45 (CVCL_7852)

[Text version]
Cell line name UT-SCC-45
Synonyms UTSCC45; University of Turku-Squamous Cell Carcinoma-45
Accession CVCL_7852
Resource Identification Initiative To cite this cell line use: UT-SCC-45 (RRID:CVCL_7852)
Comments Doubling time: 1.3 days (PubMed=29156801).
Transformant: NCBI_TaxID; 10586; Human papillomavirus type 33 (HPV33).
Omics: Deep exome analysis.
Omics: Genome sequenced (low read coverage).
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Gly72Arg (c.214G>A); ClinVar=VCV002164792; Zygosity=Homozygous (PubMed=31541927).
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): PubMed=29156801; PubMed=33802339

Markers:
AmelogeninX
CSF1PO10,12
D2S133819
D3S135815
D5S81811,12
D7S82011,12
D8S117913,18
D13S31711,14
D16S5399,13
D18S5115
D19S43314,15
D21S1131.2
FGA21,23
TH017,9.3
TPOX11
vWA18,20

Run an STR similarity search on this cell line
Publications

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I., Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143
Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Cancers (Basel) 13:1069.1-1069.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7852
Encyclopedic resources Wikidata; Q54992135
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number13